Dynamic Reorganization of the Cytoskeleton during Apoptosis: The Two Coffins Hypothesis

Autor:	Povea-Cabello, Suleva, Oropesa-Avila, Manuel, de la Cruz-Ojeda, Patricia, Villanueva-Paz, Marina, de la Mata, Mario, Miguel Suarez-Rivero, Juan, Alvarez-Cordoba, Monica, Villalon-Garcia, Irene, Cotan, David, Ybot-Gonzalez, Patricia, Sanchez-Alcazar, Jose A.
Přispěvatelé:	[Povea-Cabello, Suleva] Univ Pablo de, Inst Salud Carlos III, Consejo Super Invest Cient, CABD, Carretera Utrera Km 1, Seville 41013, Spain, [Oropesa-Avila, Manuel] Univ Pablo de, Inst Salud Carlos III, Consejo Super Invest Cient, CABD, Carretera Utrera Km 1, Seville 41013, Spain, [de la Cruz-Ojeda, Patricia] Univ Pablo de, Inst Salud Carlos III, Consejo Super Invest Cient, CABD, Carretera Utrera Km 1, Seville 41013, Spain, [Villanueva-Paz, Marina] Univ Pablo de, Inst Salud Carlos III, Consejo Super Invest Cient, CABD, Carretera Utrera Km 1, Seville 41013, Spain, [de la Mata, Mario] Univ Pablo de, Inst Salud Carlos III, Consejo Super Invest Cient, CABD, Carretera Utrera Km 1, Seville 41013, Spain, [Miguel Suarez-Rivero, Juan] Univ Pablo de, Inst Salud Carlos III, Consejo Super Invest Cient, CABD, Carretera Utrera Km 1, Seville 41013, Spain, [Alvarez-Cordoba, Monica] Univ Pablo de, Inst Salud Carlos III, Consejo Super Invest Cient, CABD, Carretera Utrera Km 1, Seville 41013, Spain, [Villalon-Garcia, Irene] Univ Pablo de, Inst Salud Carlos III, Consejo Super Invest Cient, CABD, Carretera Utrera Km 1, Seville 41013, Spain, [Cotan, David] Univ Pablo de, Inst Salud Carlos III, Consejo Super Invest Cient, CABD, Carretera Utrera Km 1, Seville 41013, Spain, [Sanchez-Alcazar, Jose A.] Univ Pablo de, Inst Salud Carlos III, Consejo Super Invest Cient, CABD, Carretera Utrera Km 1, Seville 41013, Spain, [Povea-Cabello, Suleva] Univ Pablo de, Inst Salud Carlos III, Consejo Super Invest Cient, Ctr Invest Biomed Red Enfermedades Raras, Carretera Utrera Km 1, Seville 41013, Spain, [Oropesa-Avila, Manuel] Univ Pablo de, Inst Salud Carlos III, Consejo Super Invest Cient, Ctr Invest Biomed Red Enfermedades Raras, Carretera Utrera Km 1, Seville 41013, Spain, [de la Cruz-Ojeda, Patricia] Univ Pablo de, Inst Salud Carlos III, Consejo Super Invest Cient, Ctr Invest Biomed Red Enfermedades Raras, Carretera Utrera Km 1, Seville 41013, Spain, [Villanueva-Paz, Marina] Univ Pablo de, Inst Salud Carlos III, Consejo Super Invest Cient, Ctr Invest Biomed Red Enfermedades Raras, Carretera Utrera Km 1, Seville 41013, Spain, [de la Mata, Mario] Univ Pablo de, Inst Salud Carlos III, Consejo Super Invest Cient, Ctr Invest Biomed Red Enfermedades Raras, Carretera Utrera Km 1, Seville 41013, Spain, [Miguel Suarez-Rivero, Juan] Univ Pablo de, Inst Salud Carlos III, Consejo Super Invest Cient, Ctr Invest Biomed Red Enfermedades Raras, Carretera Utrera Km 1, Seville 41013, Spain, [Alvarez-Cordoba, Monica] Univ Pablo de, Inst Salud Carlos III, Consejo Super Invest Cient, Ctr Invest Biomed Red Enfermedades Raras, Carretera Utrera Km 1, Seville 41013, Spain, [Villalon-Garcia, Irene] Univ Pablo de, Inst Salud Carlos III, Consejo Super Invest Cient, Ctr Invest Biomed Red Enfermedades Raras, Carretera Utrera Km 1, Seville 41013, Spain, [Cotan, David] Univ Pablo de, Inst Salud Carlos III, Consejo Super Invest Cient, Ctr Invest Biomed Red Enfermedades Raras, Carretera Utrera Km 1, Seville 41013, Spain, [Sanchez-Alcazar, Jose A.] Univ Pablo de, Inst Salud Carlos III, Consejo Super Invest Cient, Ctr Invest Biomed Red Enfermedades Raras, Carretera Utrera Km 1, Seville 41013, Spain, [Ybot-Gonzalez, Patricia] Hosp Univ Virgen Rocio, Inst Biomed Sevilla IBIS, Grp Neurodesarrollo, Unidad Gest Pediat, Seville 41013, Spain, Instituto de Salud Carlos III, Spain, Fondo Europeo de Desarrollo Regional (FEDER-Union Europea), AEPMI (Asociacion de Enfermos de Patologia Mitocondrial), ENACH (Asociacion de Enfermos de Neurodegeneracion con Acumulacion Cerebral de Hierro)
Jazyk:	angličtina
Rok vydání:	2017
Předmět:	Protein apoptosis apoptotic microtubule network Activation Microtubule dynamics genotoxic drugs microtubules Programmed cell-death Genetic-control Intermediate-filaments actin filaments Secondary necrosis Execution phase Pathways Cycle entry
Popis:	During apoptosis, cells undergo characteristic morphological changes in which the cytoskeleton plays an active role. The cytoskeleton rearrangements have been mainly attributed to actinomyosin ring contraction, while microtubule and intermediate filaments are depolymerized at early stages of apoptosis. However, recent results have shown that microtubules are reorganized during the execution phase of apoptosis forming an apoptotic microtubule network (AMN). Evidence suggests that AMN is required to maintain plasma membrane integrity and cell morphology during the execution phase of apoptosis. The new two coffins hypothesis proposes that both AMN and apoptotic cells can adopt two morphological patterns, round or irregular, which result from different cytoskeleton kinetic reorganization during the execution phase of apoptosis induced by genotoxic agents. In addition, round and irregular-shaped apoptosis showed different biological properties with respect to AMN maintenance, plasma membrane integrity and phagocyte responses. These findings suggest that knowing the type of apoptosis may be important to predict how fast apoptotic cells undergo secondary necrosis and the subsequent immune response. From a pathological point of view, round-shaped apoptosis can be seen as a physiological and controlled type of apoptosis, while irregular-shaped apoptosis can be considered as a pathological type of cell death closer to necrosis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=od______2636::6a05435d84c53347674bc1b6fb7364e4 https://www.mdpi.com/1422-0067/18/11/2393/pdf?version=1510536194 Zobrazit plný text záznamu