Gut and Endometrial Microbiome Dysbiosis: A New Emergent Risk Factor for Endometrial Cancer
| Autor: | Boutriq, Soukaina, González-González, Alicia, Plaza-Andrades, Isaac, Laborda-Illanes, Aurora, Sánchez-Alcoholado, Lidia, Peralta-Linero, Jesús, Domínguez-Recio, María Emilia, Bermejo-Pérez, María José, Lavado-Valenzuela, Rocío, Alba, Emilio, Queipo-Ortuño, María Isabel |
|---|---|
| Přispěvatelé: | [Boutriq,S, González-González,A, Plaza-Andrades,I, Laborda-Illanes,A, Sánchez-Alcoholado,L, Peralta-Linero,J, Domínguez-Recio,ME, Bermejo-Pérez,MJ, Alba, Queipo-Ortuño,MI] Unidad de Gestión Clínica Intercentros de Oncología Médica, Hospitales Universitarios Regional y Virgen de la Victoria, Instituto de Investigación Biomédica de Málaga (IBIMA)-CIMES-UMA, Málaga, Spain. [Boutriq,S, Lavado-Valenzuela,R, Queipo-Ortuño,MI] Instituto de Investigación Biomédica de Málaga (IBIMA), Campus de Teatinos s/n, Málaga, Spain. [Boutriq,S, Sánchez-Alcoholado,L] Facultad de Medicina, Universidad de Málaga, Málaga, Spain. [Queipo-Ortuño,MI] Centro de Investigación Biomédica en Red de Cáncer (Ciberonc CB16/12/00481), Madrid, Spain., Maria Isabel Queipo-Ortuño is recipient of a 'Miguel Servet Type II' program (CPI13/00003) from ISCIII, co-funded by the Fondo Europeo de Desarrollo Regional-FEDER, Madrid, Spain and also belongs to the regional 'Nicolas Monardes' research program of the Consejería de Salud (C-0030-2018, Junta de Andalucía, Spain. Alicia González-González is recipient of a postdoctoral contract of ALIANZA MIXTA EN RED ANDALUCÍA-ROCHE EN ONCOLOGÍA MÉDICA DE PRECISIÓN (INVESTIGACIÓN BÁSICA/TRASLACIONAL). Aurora Laborda-Illanes was recipient of a predoctoral grant, PFIS-ISCIII (FI19-00112) co-funded by the Fondo Europeo de Desarrollo Regional-FEDER, Madrid, Spain. Lidia Sanchez-Alcoholado was recipient of a predoctoral grant (PE-0106-2019) from the Consejería de Salud y Familia (co-funded by the Fondo Europeo de Desarrollo Regional-FEDER, Andalucia, Spain). |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Inflammation
Gut microbiome Prebióticos Endometrial microbiome Estrogen metabolism Microbioma gastrointestinal Inflamación Probiotics Disbiosis Anatomy::Urogenital System::Genitalia::Genitalia Female::Uterus [Medical Subject Headings] Probióticos Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Physiological Effects of Drugs::Hormones Hormone Substitutes and Hormone Antagonists::Hormones::Estrogens [Medical Subject Headings] Prebiotics Phenomena and Processes::Microbiological Phenomena::Microbiota [Medical Subject Headings] Endometrial cancer Dysbiosis Neoplasias endometriales Analytical Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis [Medical Subject Headings] Estrobolome Disciplines and Occupations::Natural Science Disciplines::Biological Science Disciplines::Biochemistry::Molecular Biology [Medical Subject Headings] Antitumour treatment Diseases::Pathological Conditions Signs and Symptoms::Pathologic Processes::Inflammation [Medical Subject Headings] Diseases::Neoplasms::Neoplasms by Site::Urogenital Neoplasms::Genital Neoplasms Female::Uterine Neoplasms::Endometrial Neoplasms [Medical Subject Headings] |
| Popis: | Endometrial cancer is one of the most common gynaecological malignancies worldwide. Histologically, two types of endometrial cancer with morphological and molecular differences and also therapeutic implications have been identified. Type I endometrial cancer has an endometrioid morphology and is estrogen-dependent, while Type II appears with non-endometrioid differentiation and follows an estrogen-unrelated pathway. Understanding the molecular biology and genetics of endometrial cancer is crucial for its prognosis and the development of novel therapies for its treatment. However, until now, scant attention has been paid to environmental components like the microbiome. Recently, due to emerging evidence that the uterus is not a sterile cavity, some studies have begun to investigate the composition of the endometrial microbiome and its role in endometrial cancer. In this review, we summarize the current state of this line of investigation, focusing on the relationship between gut and endometrial microbiome and inflammation, estrogen metabolism, and different endometrial cancer therapies. Yes |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|