Role of immune escape mechanisms in Hodgkin's lymphoma development and progression: a whole new world with therapeutic implications
| Autor: | Lejeune, Marylène, Nogales Fernández, Esteban, Henao Carrasco, Fernando, Grueso López, Ana, Illescas Vacas, Ana, Pulla, Mariano Provencio, Callau, Cristina, Álvaro, Tomás |
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| Přispěvatelé: | [de la Cruz-Merino,L, Nogales Fernández,E, Henao Carrasco,F, Grueso López,A] Clinical Oncology Department, Hospital Universitario Virgen Macarena, Sevilla, Spain. [Lejeune,M, Callau,C] Molecular Biology and Research Section, Hospital de Tortosa Verge de la Cinta and IISPV, URV, Reus, Spain. [Illescas Vacas,A] Radiotherapy Department, Hospital Universitario Virgen Macarena, Sevilla, Spain.[Pulla,MP] Clinical Oncology Department, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain. [Álvaro,T] Pathology Department, Hospital de Tortosa Verge de la Cinta and IISPV, URV, Reus, Spain. |
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Chemicals and Drugs::Amino Acids
Peptides and Proteins::Peptides::Intercellular Signaling Peptides and Proteins::Cytokines [Medical Subject Headings] Phenomena and Processes::Immune System Phenomena::Immunocompromised Host [Medical Subject Headings] Anatomy::Cells::Reed-Sternberg Cells [Medical Subject Headings] Anatomy::Cells::Antigen-Presenting Cells::Dendritic Cells [Medical Subject Headings] Diseases::Pathological Conditions Signs and Symptoms::Pathologic Processes::Disease Attributes::Disease Progression [Medical Subject Headings] Células dendríticas Phenomena and Processes::Immune System Phenomena::Immune System Processes::Tumor Escape [Medical Subject Headings] Diseases::Neoplasms::Neoplasms by Histologic Type::Lymphoma::Hodgkin Disease [Medical Subject Headings] Huésped inmunocomprometido Phenomena and Processes::Cell Physiological Phenomena::Cellular Microenvironment::Tumor Microenvironment [Medical Subject Headings] Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings] Microambiente tumoral Anatomy::Cells::Blood Cells::Leukocytes::Leukocytes Mononuclear::Lymphocytes::Killer Cells Natural [Medical Subject Headings] Anatomy::Cells::Connective Tissue Cells::Macrophages [Medical Subject Headings] Progresión de la enfermedad Células de Reed-Sternberg Enfermedad de Hodgkin Analytical Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Biological Therapy::Immunomodulation::Immunotherapy [Medical Subject Headings] Anatomy::Cells::Blood Cells::Leukocytes::Leukocytes Mononuclear::Lymphocytes [Medical Subject Headings] Macrófagos Anatomy::Cells::Blood Cells::Leukocytes::Granulocytes::Neutrophils [Medical Subject Headings] |
| Popis: | Journal Article; Review; Hodgkin's lymphoma represents one of the most frequent lymphoproliferative syndromes, especially in young population. Although HL is considered one of the most curable tumors, a sizeable fraction of patients recur after successful upfront treatment or, less commonly, are primarily resistant. This work tries to summarize the data on clinical, histological, pathological, and biological factors in HL, with special emphasis on the improvement of prognosis and their impact on therapeutical strategies. The recent advances in our understanding of HL biology and immunology show that infiltrated immune cells and cytokines in the tumoral microenvironment may play different functions that seem tightly related with clinical outcomes. Strategies aimed at interfering with the crosstalk between tumoral Reed-Sternberg cells and their cellular partners have been taken into account in the development of new immunotherapies that target different cell components of HL microenvironment. This new knowledge will probably translate into a change in the antineoplastic treatments in HL in the next future and hopefully will increase the curability rates of this disease. Yes |
| Databáze: | OpenAIRE |
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