Advances in the Knowledge of the Molecular Biology of Glioblastoma and Its Impact in Patient Diagnosis, Stratification, and Treatment
| Autor: | Delgado-Martín, Belén, Medina, Miguel Ángel |
|---|---|
| Přispěvatelé: | [Delgado-Martín,B, Medina,MA] Department of Molecular Biology and Biochemistry Faculty of Sciences, University of Málaga Málaga, Spain. [Medina,MA] IBIMA (Biomedical Research Institute of Málaga) Málaga, Spain. [Medina,MA] CIBER de Enfermedades Raras (CIBERER) Málaga, Spain., This work received funds from grants PID2019-105010RB-I00 (Spanish Ministry of Science, Innovation and Universities), UMA18-FEDERJA-220 (Andalusian Government and FEDER), group BIO 267 (Andalusian Government), as well as 'Plan Propio de Investigación y Transferencia' (U. Málaga). The 'CIBER de Enfermedades Raras' is an initiative from the ISCIII (Spain). |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Health Care::Health Care Economics and Organizations::Organizations::International Agencies::United Nations::World Health Organization [Medical Subject Headings]
Disciplines and Occupations::Natural Science Disciplines::Biological Science Disciplines::Biology::Genetics [Medical Subject Headings] Disciplines and Occupations::Natural Science Disciplines::Biological Science Disciplines::Biology::Genetics::Molecular Biology [Medical Subject Headings] Cancer therapy Patient stratification Diagnóstico Terapéutica Diseases::Neoplasms::Neoplasms by Site::Nervous System Neoplasms::Central Nervous System Neoplasms::Brain Neoplasms [Medical Subject Headings] Analytical Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Combined Modality Therapy::Chemotherapy Adjuvant [Medical Subject Headings] Chemicals and Drugs::Pharmaceutical Preparations [Medical Subject Headings] Anatomy::Nervous System::Central Nervous System::Brain [Medical Subject Headings] Neoplasias Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings] Diseases::Neoplasms::Neoplasms by Histologic Type::Neoplasms Glandular and Epithelial::Neoplasms Neuroepithelial::Glioma [Medical Subject Headings] Preparaciones farmacéuticas Encéfalo Analytical Diagnostic and Therapeutic Techniques and Equipment::Diagnosis [Medical Subject Headings] Diseases::Neoplasms::Neoplasms by Histologic Type::Neoplasms Glandular and Epithelial::Neoplasms Neuroepithelial::Glioma::Astrocytoma::Glioblastoma [Medical Subject Headings] Glioblastoma Diagnostics |
| Popis: | Gliomas are the most common primary brain tumors in adults. They arise in the glial tissue and primarily occur in the brain. Low-grade tumors of World Health Organization (WHO) grade II tend to progress to high-grade gliomas of WHO grade III and, eventually, glioblastoma of WHO grade IV, which is the most common and deadly glioma, with a median survival of 12-15 months after final diagnosis. Knowledge of the molecular biology and genetics of glioblastoma has increased significantly in the past few years, giving rise to classification methods that can help in management and stratification of glioblastoma patients. However, glioblastoma remains an incurable disease. Glioblastoma cells have acquired genetic and metabolic adaptations in order to sustain tumor growth and progression, including changes in energetic metabolism, invasive capacity, migration, and angiogenesis, that make it very difficult to find suitable therapeutic targets and to develop effective drugs. The current standard of care for glioblastoma patients is surgery followed by radiotherapy plus concomitant and adjuvant chemotherapy with temozolomide. Although progress in glioblastoma therapies in recent years has been more limited than in other tumors, numerous drugs and targets are being proposed and many clinical trials are underway to develop effective subtype-specific treatments. Yes |
| Databáze: | OpenAIRE |
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