From Grafts to Human Bioengineered Vascularized Skin Substitutes
| Autor: | Oualla-Bachiri, Wasima, Fernández-González, Ana, Quiñones-Vico, María I., Arias-Santiago, Salvador |
|---|---|
| Přispěvatelé: | [Oualla-Bachiri,W, Fernández-González,A, Quiñones-Vico,MI, Arias-Santiago,S] Cell Production and Tissue Engineering Unit, Virgen de las Nieves University Hospital, Granada, Spain. [Oualla-Bachiri,W, Arias-Santiago,S] Biosanitary Institute of Granada (ibs. GRANADA), Granada, Spain. [Oualla-Bachiri,W, Arias-Santiago,S] Andalusian Network of Design and Translation of Advanced Therapies, Sevilla, Spain. [Arias-Santiago,S] Dermatology Department, Virgen de las Nieves University Hospital, Granada, Spain. [Arias-Santiago,S] Dermatology Department, School of Medicine, Granada University, Granada, Spain., We gratefully acknowledge financial support from Instituto de Salud Carlos III through the projects PI-13/02576 and PI-17/02083 (co-funded by European Regional Development Fund 'A way to make Europe') and Ministry of Health of the Andalusian Regional Government (SAS PI-0458-2016). |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Endothelial cells
Wound healing Anatomy::Tissues::Connective Tissue::Subcutaneous Tissue [Medical Subject Headings] Grafts Analytical Diagnostic and Therapeutic Techniques and Equipment::Equipment and Supplies::Surgical Equipment::Artificial Organs::Skin Artificial [Medical Subject Headings] Anatomy::Body Regions::Transplants::Allografts [Medical Subject Headings] Skin substitutes Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings] Phenomena and Processes::Chemical Phenomena::Physicochemical Phenomena::Surface Properties::Adhesiveness [Medical Subject Headings] Organisms::Eukaryota::Animals [Medical Subject Headings] Tissue engineering Piel Artificial Diseases::Pathological Conditions Signs and Symptoms::Pathologic Processes::Metaplasia::Neovascularization Pathologic [Medical Subject Headings] Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Culture Techniques::Cell Engineering::Tissue Engineering [Medical Subject Headings] integumentary system Analytical Diagnostic and Therapeutic Techniques and Equipment::Surgical Procedures Operative::Transplantation::Tissue Transplantation::Skin Transplantation [Medical Subject Headings] Vascularization Inductores de la angiogénesis Trilayered Anatomy::Body Regions::Transplants [Medical Subject Headings] Anatomy::Integumentary System::Skin [Medical Subject Headings] Phenomena and Processes::Biological Phenomena::Biological Processes::Regeneration::Wound Healing [Medical Subject Headings] Phenomena and Processes::Biological Phenomena::Biological Processes::Regeneration [Medical Subject Headings] Angiogenesis Trasplantes Phenomena and Processes::Physical Phenomena::Biophysical Phenomena::Biomechanical Phenomena [Medical Subject Headings] Células Endoteliales |
| Popis: | The skin plays an important role in the maintenance of the human's body physiological homeostasis. It acts as a coverage that protects against infective microorganism or biomechanical impacts. Skin is also implied in thermal regulation and fluid balance. However, skin can suffer several damages that impede normal wound-healing responses and lead to chronic wounds. Since the use of autografts, allografts, and xenografts present source limitations and intense rejection associated problems, bioengineered artificial skin substitutes (BASS) have emerged as a promising solution to address these problems. Despite this, currently available skin substitutes have many drawbacks, and an ideal skin substitute has not been developed yet. The advances that have been produced on tissue engineering techniques have enabled improving and developing new arising skin substitutes. The aim of this review is to outline these advances, including commercially available skin substitutes, to finally focus on future tissue engineering perspectives leading to the creation of autologous prevascularized skin equivalents with a hypodermal-like layer to achieve an exemplary skin substitute that fulfills all the biological characteristics of native skin and contributes to wound healing. Yes |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|