Heme Oxygenase-1 in Gastrointestinal Tract Health and Disease
| Autor: | Puentes-Pardo, Jose D., Moreno-SanJuan, Sara, Carazo, Ángel, León, Josefa |
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| Přispěvatelé: | [Puentes-Pardo,JD, León,J] Research Unit, Instituto de Investigacion Biosanitaria de Granada, ibs.GRANADA, Granada, Spain. [Puentes-Pardo,JD] Department of Pharmacology, Faculty of Pharmacy, University of Granada, Granada, Spain. [Moreno-SanJuan,S] Cytometry and Microscopy Research Service, Instituto de Investigacion Biosanitaria de Granada, ibs.GRANADA, Granada, Spain. [Carazo,A] Genomic Research Service, Instituto de Investigacion Biosanitaria de Granada, ibs.GRANADA, Granada, Spain. [León,J] Clinical Management Unit of Digestive Disease, San Cecilio University Hospital, Granada, Spain., This work was supported by a research grant from the Instituto de Salud Carlos III-FEDER (PI18/01947). J.L. was supported by the Nicolás Monardes Program from the Andalusian Health Service (C-0033-2015). J.D.P.-P. is funded by a FPU2019 fellowship (FPU19/02269) from the Ministerio de Ciencia, Innovación y Universidades (Spain). |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Enfermedades inflamatorias del intestino
Diseases::Endocrine System Diseases::Diabetes Mellitus [Medical Subject Headings] Diabetes Peptic ulcer disease Diseases::Digestive System Diseases::Liver Diseases::Fatty Liver [Medical Subject Headings] Úlcera péptica Enfermedad del hígado graso no alcohólico Diseases::Neoplasms [Medical Subject Headings] Inflammatory bowel disease Neoplasias Heme oxygenase Diseases::Digestive System Diseases::Gastrointestinal Diseases::Gastroenteritis::Inflammatory Bowel Diseases [Medical Subject Headings] Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings] Diabetes mellitus Gastrointestinal tract Pancreatitis Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Oxidoreductases::Oxygenases::Mixed Function Oxygenases::Heme Oxygenase (Decyclizing)::Heme Oxygenase-1 [Medical Subject Headings] Fatty liver disease Hemo-oxigenasa 1 Ferroptosis Anatomy::Digestive System::Gastrointestinal Tract [Medical Subject Headings] Diseases::Digestive System Diseases::Gastrointestinal Diseases::Peptic Ulcer [Medical Subject Headings] Diseases::Digestive System Diseases::Pancreatic Diseases::Pancreatitis [Medical Subject Headings] Cancer Tracto gastrointestinal |
| Popis: | Heme oxygenase 1 (HO-1) is the rate-limiting enzyme of heme oxidative degradation, generating carbon monoxide (CO), free iron, and biliverdin. HO-1, a stress inducible enzyme, is considered as an anti-oxidative and cytoprotective agent. As many studies suggest, HO-1 is highly expressed in the gastrointestinal tract where it is involved in the response to inflammatory processes, which may lead to several diseases such as pancreatitis, diabetes, fatty liver disease, inflammatory bowel disease, and cancer. In this review, we highlight the pivotal role of HO-1 and its downstream effectors in the development of disorders and their beneficial effects on the maintenance of the gastrointestinal tract health. We also examine clinical trials involving the therapeutic targets derived from HO-1 system for the most common diseases of the digestive system. Yes |
| Databáze: | OpenAIRE |
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