Cancer stem cell secretome in the tumor microenvironment: a key point for an effective personalized cancer treatment
| Autor: | López de Andrés, Julia, Griñán-Lisón, Carmen, Jiménez, Gema, Marchal, Juan Antonio |
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| Přispěvatelé: | [López de Andrés,J, Griñán-Lisón,C, Jiménez,G, Marchal,JA] Biopathology and Regenerative Medicine Institute (IBIMER), Centre for Biomedical Research (CIBM), University of Granada,Granada, Spain. [López de Andrés,J, Marchal,JA] Instituto de Investigación Biosanitaria Ibs.GRANADA, University Hospitals of Granada-University of Granada, Granada, Spain. [López de Andrés,J, Marchal,JA] Excellence Research Unit 'Modeling Nature' (MNat), University of Granada, Granada, Spain. [Jiménez,G] Department of Health Sciences, University of Jaén, Jaén, Spain. [Marchal,JA] Department of Human Anatomy and Embryology, Faculty of Medicine, University of Granada, Granada, Spain., This work was supported by grants from Consejería de Salud y Familias de la Junta de Andalucía (Project Numbers PIN-0224-2019), by the Ministerio de Ciencia, Innovación y Universidades Grant Number RTI2018-101309-B-C22 (FEDER Funds), by the Consejería de Economía, Conocimiento, Empresas y Universidad de la Junta de Andalucía (P18-FR-2470 and SOMM17/6109/UGR, FEDER Funds), by the Ministry of Economy and Competitiveness, Instituto de Salud Carlos III (FEDER funds, Projects Nos. PIE16/00045, DTS19/00143 and DTS17/00087), and from the Chair 'Doctors Galera-Requena in cancer stem cell research' (CMC-CTS963) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Células madre neoplásicas
Anatomy::Cells::Cellular Structures::Extracellular Space::Extracellular Matrix [Medical Subject Headings] MicroARNs Chemicals and Drugs::Biological Factors::Intercellular Signaling Peptides and Proteins::Cytokines::Interleukins [Medical Subject Headings] Cancer stem cells Péptidos y proteínas de señalización intercelular Interleukins Phenomena and Processes::Cell Physiological Phenomena::Cellular Microenvironment::Tumor Microenvironment [Medical Subject Headings] Anatomy::Cells::Stem Cells::Neoplastic Stem Cells [Medical Subject Headings] Chemicals and Drugs::Nucleic Acids Nucleotides and Nucleosides::Nucleic Acids::RNA::RNA Antisense::MicroRNAs [Medical Subject Headings] Diseases::Neoplasms [Medical Subject Headings] Exosomes Chemicals and Drugs::Biological Factors::Intercellular Signaling Peptides and Proteins [Medical Subject Headings] Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings] Tumor microenvironment Factores de crecimiento endotelial vascular Microambiente tumoral Interleucinas miRNAs Organisms::Eukaryota::Animals [Medical Subject Headings] Anatomy::Cells::Cellular Structures::Intracellular Space::Cytoplasm::Cytoplasmic Structures::Organelles::Cytoplasmic Vesicles::Transport Vesicles::Exosomes [Medical Subject Headings] Growth factors Diseases::Pathological Conditions Signs and Symptoms::Pathologic Processes::Metaplasia::Neovascularization Pathologic [Medical Subject Headings] Secretome |
| Popis: | Cancer stem cells (CSCs) represent a tumor subpopulation responsible for tumor metastasis and resistance to chemo- and radiotherapy, ultimately leading to tumor relapse. As a consequence, the detection and eradication of this cell subpopulation represent a current challenge in oncology medicine. CSC phenotype is dependent on the tumor microenvironment (TME), which involves stem and differentiated tumor cells, as well as different cell types, such as mesenchymal stem cells, endothelial cells, fibroblasts and cells of the immune system, in addition to the extracellular matrix (ECM), different in composition to the ECM in healthy tissues. CSCs regulate multiple cancer hallmarks through the interaction with cells and ECM in their environment by secreting extracellular vesicles including exosomes, and soluble factors such as interleukins, cytokines, growth factors and other metabolites to the TME. Through these factors, CSCs generate and activate their own tumor niche by recruiting stromal cells and modulate angiogenesis, metastasis, resistance to antitumor treatments and their own maintenance by the secretion of different factors such as IL-6, VEGF and TGF-ß. Due to the strong influence of the CSC secretome on disease development, the new antitumor therapies focus on targeting these communication networks to eradicate the tumor and prevent metastasis, tumor relapse and drug resistance. This review summarizes for the first time the main components of the CSC secretome and how they mediate different tumor processes. Lastly, the relevance of the CSC secretome in the development of more precise and personalized antitumor therapies is discussed. Yes |
| Databáze: | OpenAIRE |
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