Iron Metabolism in Obesity and Metabolic Syndrome
| Autor: | González-Domínguez, Álvaro, Visiedo-García, Francisco M., Domínguez-Riscart, Jesús, González-Domínguez, Raúl, Mateos, Rosa M., Lechuga-Sancho, Alfonso María |
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| Přispěvatelé: | [González-Domínguez,A, Visiedo-García,FM, Mateos,RM, Lechuga-Sancho,AM] Inflammation, Nutrition, Metabolism and Oxidative Stress Study Group (INMOX), Biomedical Research and Innovation Institute of Cádiz (INiBICA), Research Unit, Puerta del Mar University Hospital, Cádiz, Spain. [Domínguez-Riscart,J, Lechuga-Sancho,AM] Pediatric Endocrinology, Department of Pediatrics, Puerta del Mar University Hospital, Cádiz, Spain. [González-Domínguez,R] Department of Chemistry, Faculty of Experimental Sciences, University of Huelva, Huelva, Spain. [Mateos,RM] Area of Biochemistry and Molecular Biology, Department of Biomedicine, Biotechnology and Public Health, University of Cádiz, Cádiz, Spain. [Lechuga-Sancho,AM] Area of Pediatrics, Department of Child and Mother Health and Radiology, Medical School, University of Cádiz, Cádiz, Spain., This research was funded by Spanish Government through the Carlos III Health Institute (Sanitary Research Fund (FIS)), code PI18/01316. A G-D is supported by an intramural grant from the Biomedical Research and Innovation Institute of Cádiz (INiBICA), code LII19/16IN-CO24. |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Síndrome metabólico
Metabolismo Iron Obesidad Diseases::Endocrine System Diseases::Diabetes Mellitus::Diabetes Mellitus Type 2 [Medical Subject Headings] Diseases::Digestive System Diseases::Liver Diseases::Fatty Liver [Medical Subject Headings] Anemia Metabolic syndrome Diseases::Nutritional and Metabolic Diseases::Nutrition Disorders::Overnutrition::Obesity [Medical Subject Headings] Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings] Metabolism Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Glucose Metabolism Disorders::Hyperinsulinism::Insulin Resistance [Medical Subject Headings] Diseases::Nutritional and Metabolic Diseases::Nutrition Disorders::Overnutrition::Obesity::Pediatric Obesity [Medical Subject Headings] Obesidad pediátrica Persons::Persons::Age Groups::Child [Medical Subject Headings] Childhood obesity Obesity Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Iron Metabolism Disorders [Medical Subject Headings] Diseases::Hemic and Lymphatic Diseases::Hematologic Diseases::Anemia [Medical Subject Headings] Diseases::Cardiovascular Diseases [Medical Subject Headings] Diseases::Pathological Conditions Signs and Symptoms::Pathologic Processes::Inflammation [Medical Subject Headings] Hierro |
| Popis: | Obesity is an excessive adipose tissue accumulation that may have detrimental effects on health. Particularly, childhood obesity has become one of the main public health problems in the 21st century, since its prevalence has widely increased in recent years. Childhood obesity is intimately related to the development of several comorbidities such as nonalcoholic fatty liver disease, dyslipidemia, type 2 diabetes mellitus, non-congenital cardiovascular disease, chronic inflammation and anemia, among others. Within this tangled interplay between these comorbidities and associated pathological conditions, obesity has been closely linked to important perturbations in iron metabolism. Iron is the second most abundant metal on Earth, but its bioavailability is hampered by its ability to form highly insoluble oxides, with iron deficiency being the most common nutritional disorder. Although every living organism requires iron, it may also cause toxic oxygen damage by generating oxygen free radicals through the Fenton reaction. Thus, iron homeostasis and metabolism must be tightly regulated in humans at every level (i.e., absorption, storage, transport, recycling). Dysregulation of any step involved in iron metabolism may lead to iron deficiencies and, eventually, to the anemic state related to obesity. In this review article, we summarize the existent evidence on the role of the most recently described components of iron metabolism and their alterations in obesity. Yes |
| Databáze: | OpenAIRE |
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