Liquid Biopsy as a Tool for the Characterisation and Early Detection of the Field Cancerization Effect in Patients with Oral Cavity Carcinoma

Autor: Pérez-Ruiz, Elisabeth, Gutiérrez, Vanesa, Muñoz, Marta, Oliver, Javier, Sánchez, Marta, Gálvez-Carvajal, Laura, Rueda-Domínguez, Antonio, Barragán, Isabel
Přispěvatelé: [Pérez-Ruiz,E, Gutiérrez,V, Muñoz,M, Gálvez-Carvajal,L, Rueda-Domínguez,A] Unidad de Gestión Clínica Intercentros de Oncología Médica, Oncology Department, Institute of Biomedical Investigation of Malaga (IBIMA), Hospitales Universitarios Regional y Virgen de la Victoria, Malaga, Spain. [Oliver,J, Barragán,I] Researcher Unit, Unidad de Gestión Clínica Intercentros de Oncología Médica, Institute of Biomedical Investigation of Malaga (IBIMA), Hospitales Universitarios Regional y Virgen de la Victoria, Malaga, Spain. [Sánchez,M] Maxillofacial Surgery Department, Hospital Regional Universitario de Málaga, Málaga, Spain. [Barragán,I] Group of Pharmacoepigenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden, E.P.-R. has received a grant from The Spanish Society of Medical Oncology (SEOM). IB has received funding (project SA 0263/2017, Nicolás Monardes Program) from the Consejería de Salud y Familias, Junta de Andalucía, Spain.
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Diseases::Pathological Conditions
Signs and Symptoms::Pathologic Processes::Disease Attributes::Recurrence [Medical Subject Headings]
Diseases::Neoplasms::Neoplasms by Site::Head and Neck Neoplasms [Medical Subject Headings]
Liquid biopsy
Analytical
Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Mortality::Survival Rate [Medical Subject Headings]
Organisms::Eukaryota::Plants::Viridiplantae::Streptophyta::Embryophyta::Angiosperms::Solanaceae::Tobacco [Medical Subject Headings]
Carcinoma de células escamosas de cabeza y cuello
Diseases::Neoplasms::Neoplasms
Second Primary [Medical Subject Headings]
Early diagnosis
Analytical
Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Factors [Medical Subject Headings]
Oral cell carcinoma
Tabaco
Diagnóstico precoz
Detección precoz del cáncer
Anatomy::Fluids and Secretions::Bodily Secretions::Saliva [Medical Subject Headings]
Psychiatry and Psychology::Behavior and Behavior Mechanisms::Motivation::Goals [Medical Subject Headings]
Diseases::Neoplasms::Neoplasms by Histologic Type::Neoplasms
Glandular and Epithelial::Carcinoma::Carcinoma
Squamous Cell [Medical Subject Headings]
Field cancerization
Tobacco
Biopsia líquida
Analytical
Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Clinical Laboratory Techniques::Cytological Techniques::Cytodiagnosis::Biopsy [Medical Subject Headings]
Analytical
Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis [Medical Subject Headings]
Analytical
Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Early Diagnosis [Medical Subject Headings]
Saliva
Diseases::Stomatognathic Diseases::Mouth Diseases::Mouth Neoplasms [Medical Subject Headings]
Popis: Oral squamous cell carcinoma (OSCC) constitutes approximately 25% of all head and neck cancer, for which the consumption of tobacco and alcohol are the main associated risk factors. The field cancerization effect of OSCC is one of the main reasons for the poor survival rates associated with this disease. Despite some advances, its ccharacterization and early diagnosis continue to challenge modern oncology, and the goal of improving the prognosis remains to be achieved. Among new early diagnostic tools for OSCC that have been proposed, liquid biopsy appears to be an ideal candidate, as studies have shown that the analysis of blood and saliva provides promising data for the early detection of relapses or second tumours. Yes
Databáze: OpenAIRE
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