The Gut Barrier, Intestinal Microbiota, and Liver Disease: Molecular Mechanisms and Strategies to Manage
| Autor: | Plaza-Díaz, Julio, Solís-Urra, Patricio, Rodríguez-Rodríguez, Fernando, Olivares-Arancibia, Jorge, Navarro-Oliveros, Miguel, Abadía-Molina, Francisco, Álvarez-Mercado, Ana I. |
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| Přispěvatelé: | [Plaza-Díaz,J] Children’s Hospital of Eastern Ontario Research Institute, Ottawa, Canada. [Plaza-Díaz,J, Álvarez-Mercado,AI] Department of Biochemistry and Molecular Biology II, School of Pharmacy, University of Granada, Granada, Spain. [Plaza-Díaz,J, Álvarez-Mercado,AI] Instituto de Investigación Biosanitaria IBS.GRANADA, Complejo Hospitalario Universitario de Granada, Granada, Spain. [Solís-Urra,P] Faculty of Education and Social Sciences, Universidad Andres Bello, Viña del Mar, Chile. [Rodríguez-Rodríguez,F, Olivares-Arancibia,J] IRyS Research Group, School of Physical Education, Pontificia Universidad Católica de Valparaíso, Valparaíso, Chile. [Olivares-Arancibia,J] Escuela de Pedagogía en Educación Física, Facultad de Educación, Universidad de las Américas, Santiago, Chile. [Navarro-Oliveros,M] BioCritic. Group for Biomedical Research in Critical Care Medicine, Valladolid, Spain. [Abadía-Molina,F, Álvarez-Mercado,AI] Institute of Nutrition and Food Technology 'José Mataix', Center of Biomedical Research, University of Granada, Armilla, Granada, Spain. [Abadía-Molina,F] Department of Cell Biology, School of Sciences, University of Granada, Granada, Spain., Patricio Solis-Urra was supported by a grant from the National Agency for Research and Development (ANID) BECAS Chile/72180543. |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Microbioma gastrointestinal
Hígado Anatomy::Digestive System::Liver [Medical Subject Headings] Microbiota Permeabilidad Diseases::Digestive System Diseases::Liver Diseases::Fatty Liver [Medical Subject Headings] Intestinal permeability Diseases::Digestive System Diseases::Liver Diseases::Liver Diseases Alcoholic [Medical Subject Headings] Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings] Phenomena and Processes::Microbiological Phenomena::Microbiota [Medical Subject Headings] Hepatopatías Diseases::Digestive System Diseases::Liver Diseases [Medical Subject Headings] Organisms::Eukaryota::Animals [Medical Subject Headings] Diseases::Pathological Conditions Signs and Symptoms::Pathologic Processes::Dysbiosis [Medical Subject Headings] Liver disease Intestinal barrier Organisms::Bacteria [Medical Subject Headings] Anatomy::Digestive System::Gastrointestinal Tract::Intestines::Intestinal Mucosa [Medical Subject Headings] |
| Popis: | Liver disease encompasses pathologies as non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, alcohol liver disease, hepatocellular carcinoma, viral hepatitis, and autoimmune hepatitis. Nowadays, underlying mechanisms associating gut permeability and liver disease development are not well understood, although evidence points to the involvement of intestinal microbiota and their metabolites. Animal studies have shown alterations in Toll-like receptor signaling related to the leaky gut syndrome by the action of bacterial lipopolysaccharide. In humans, modifications of the intestinal microbiota in intestinal permeability have also been related to liver disease. Some of these changes were observed in bacterial species belonging Roseburia, Streptococcus, and Rothia. Currently, numerous strategies to treat liver disease are being assessed. This review summarizes and discusses studies addressed to determine mechanisms associated with the microbiota able to alter the intestinal barrier complementing the progress and advancement of liver disease, as well as the main strategies under development to manage these pathologies. We highlight those approaches that have shown improvement in intestinal microbiota and barrier function, namely lifestyle changes (diet and physical activity) and probiotics intervention. Nevertheless, knowledge about how such modifications are beneficial is still limited and specific mechanisms involved are not clear. Thus, further in-vitro, animal, and human studies are needed. Yes |
| Databáze: | OpenAIRE |
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