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© 2023 Turkish Society of Cardiology. All rights reserved.Objective: Diabetes mellitus (DM) progresses with dynamic changes in renal blood flow and glomerular filtration. Renal frame count (RFC) is a cineangiographical parameter that is capable of presenting microvascular and macrovascular changes in the renal blood flow. We aimed to show the changes, which may be caused by DM in the perfusion, by using RFC. Methods: A total of 110 hypertensive subjects consisting of 55 DM patients and 55 non-DM patients, as a control group who underwent renal angiography, were retrospectively enrolled in the study. The RFC values of all subjects were calculated and compared to each other. Results: There were no significant differences between the two groups in terms of basal demographic characteristics and antihypertensive medications. The RFC value measured from the left renal artery was significantly lower in the DM group compared to the control group (11.33 ± 2.55, 13.49 ± 3.24, respectively; P |