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Objectives : The occurrence of depression in people with epilepsy is almost twice as common as in the general population. Furthermore, depression is the first cause of lower quality of life among those patients. That’s why the main goal of this study was to assess the epidemiology of depression and its associated factors among the patients from the tertiary department of epileptology in Rennes. Methods/Results : The subjects were included prospectively and consecutively at the moment of their consultation or hospitalisation in the department. Personnel data about the socio-economic status and the type of epilepsy was collected. The subjects filled validated self-assessment of depression (NDDIE), anxiety (GAD-7) and quality of life (QOLIE-10). Thanks to the NDDIE, the patients were divided in : “depressed” and “not depressed” ; and the two groups were compared with univariate and multivariate models. 322 patients have been followed-up in the department between the 17th of June and the 9th of September 2016, among them 223 were included in the study. According to the NDDIE, 22.6% suffered from depression ; according to the GAD-7, 46.4% suffered from anxiety. In the “depressed” group, 82% were not under anti-depressant medication. In univariate model, depression was associated with : anxiety, suicidal ideations, lower quality of life, vague nervus stimulation treatment, anticonvulsant benzodiazepine medication or psychiatric medication, and last of all bitherapy or polytherapy antiepileptic medication compared to monotherapy. In multivariate model, depression was significantly related with anxiety (OR : 8.86 [3.00 ; 26.19] p=0.0001), suicidal ideations (OR : 7.43 [2.93 ; 18.81] p |
