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Introduction: the influence of tobacco consumption on the expression of celiac disease (CD) is unknown. The objectives of this study were to investigate the effects of tobacco consumption on the severity of CD at diagnosis, the age at CD diagnosis, and on occurrence of complicated forms of CD. Methods: a retrospective study was conducted at the European Georges Pompidou Hospital, Paris. Among 596 patients with a diagnosis of CD, followed between 2000 and 2014, those diagnosed during adulthood with available smoking data were included. Severity criterions collected at the time of diagnosis were the presence of typical digestive symptoms, anemia, hypoalbuminemia, bone demineralization and total villous atrophy. Age at CD diagnosis and occurrence of complicated forms of CD such as refractory sprue or intestinal lymphoma were also collected. Results: 259 patients were included, comprising 22.8% active smokers, 56.4% non-smokers, and 20.8% former smokers at the time of CD diagnosis. The proportion of typical digestive symptoms, anemia, hypoalbuminemia, bone demineralization and total villous atrophy were similar, regardless of the smoking status (p> 0.05). The median age at CD diagnosis was 31 years for active smokers versus 38 years for non-smokers, p 0,05). L’âge médian au diagnostic était de 31 ans pour les fumeurs actifs versus 38 ans pour les non fumeurs, p |
