| Autor: |
VRILLON, Agathe |
| Přispěvatelé: |
Université Paris Descartes - Faculté de Médecine (UPD5 Médecine), Université Paris Descartes - Paris 5 (UPD5), Élodie Hainque |
| Jazyk: |
francouzština |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
Médecine humaine et pathologie. 2019 |
| Popis: |
Introduction: deep brain stimulation of the subthalamic nucleus (STN-DBS) improves motor state in advanced Parkinson's disease (PD). Dyskinesia is among the symptoms that reduce the most the quality of life at the stage of motor fluctuations. The aims of our study were to i) assess the evolution of dyskinesia at one year after STN-DBS, ii) identify predictors of the outcome and iii) identify an optimal location of active contacts to obtain improvement of dyskinesia. Materials and methods: we included 269 patients from the Predi-Stim multicenter prospective cohort, who underwent STN-DBS and had had evaluation at one year post-surgery. The primary endpoint was the UPDRS IV dyskinesia sub-scores 4.1 + 4.2 + 4.6 (UPDRS DSK) scored at baseline and at one year follow-up. Motor and neuropsychiatric clinical data were collected pre-operatively and at one year. Pre-surgery cerebral MRI and post-surgery CT-scan were collected and treated to locate active contacts. Logistic regression analysis was performed to identify independent predictors of outcome. An analysis by ROC curve was made in order to establish a threshold of UPDRS IV DSK at inclusion allowing to determine outcome. Results: dyskinesia was improved at one-year follow-up in 82,4% of patients: the UPDRS DSK mean score decreased from 3.26 +-2.31 to 1.3 +-1.73 (p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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