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Introduction: No evidence exist regarding the prevalence of different patterns of hypoxia throughout the 24 hours and their underlying mechanisms. Study Objectives: Determine the prevalence of diurnal or nocturnal hypoxia (NH) and the associated factors. Methods: 183 stable CHF (chronic heart failure) patients from Grenoble university hospital, with optimized medical treatment, were enrolled in this prospective cohort. They systematically underwent a cardiorespiratory sleep recording, a complete pulmonary function test assessment and arterial blood gazes. 86.3% of patients were men with a mean age of 67 years, and BMI of 27 kg/m². They were mainly in class II-III NYHA, with a mean LVEF of 38%. CHF etiology was ischemic cardiomyopathy in 55.61% of patients. They exhibited multiple comorbidities and airflow obstruction was present in 35.06%. Only 8 patients (4.37%) were hypoxic during daytime and always associated with nocturnal hypoxia with a SAS in 100% of cases. NH (T90> 20min) was found in 87% of CHF and was explained by the presence of sleep apnea syndrome (SAS) in all but 3 patients (only 1, 67% had nocturnal hypoxia without SAS). SAS was found in 85% of CHF, with a mean AHI of 33.53/h (AHI > 30/h in 48.63% of them and 40% were central). In Univariate analysis, NH was associated with higher BMI and BNP level and Lower DLCO level. In multivariate analysis, only SAS severity (p 20min) a été observée pour 87% avec un SAS chez tous sauf 3 (seul 1,67% avaient une HN sans SAS associé). Un SAS a été trouvé chez 85% des patients (IAH moyen 33,53 / h; IAH> 30 / h pour 48,63% des SAS; SAS central dans 40% des cas). En analyse univariée, l’HN était associée à un IMC et des NT-proBNP élevés et une DLCO basse. En l'analyse multivariée, seule la sévérité du SAS (p |
