Recombinant vaccine for diseases caused by encapsulated organisms

Přispěvatelé:	Virginia Tech Intellectual Properties, Inc., Inzana, Thomas J., Ward, Christine
Jazyk:	angličtina
Rok vydání:	1996
Předmět:	C07K14/285 424/825 animal diseases A61K2039/522 435/245 424/235.1 435/440 435/243 424/93.2 424/256.1 435/471 A61K2039/552 A61K39/0002 Y10S424/825 A61K39/102 435/252.3
Popis:	Vaccines for diseases caused by normally encapsulated organisms are produced by genetically modifying those organisms by deleting the genes encoding for capsule synthesis or a portion thereof sufficient to produce non-capsulated mutants of the organisms. As an example, a live, attenuated strain of Actinobacillus pleuropneumoniae genetically modified with a large deletion in a chromosomal regions of the DNA which encodes for capsule synthesis is a safe and effective vaccine against swine pleuropneumonia.
Databáze:	OpenAIRE
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