| Autor: |
Khashana, A. (Abdelmoneim), Ahmed, H. (Hoda), Ahmed, A. (Amal), Abdelwahab, A. (Amina), Saarela, T. (Timo), Rämet, M. (Mika), Hallman, M. (Mikko) |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Předmět: |
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| Popis: |
Objective: To correlate between cortisol precursors in neonates with vasopressor resistant hypotension and demographic characteristics. Methods: We investigated 48 neonates with vasopressor-resistant hypotension. Gestation at birth ranged from 34 to 42 weeks and postnatal age from 4 to 14 days. Cortisol and precursor steroids were measured soon after the onset of volume expansion and inotropes for treatment of shock. Their concentrations were determined using liquid chromatography/mass spectrometry. Results: In neonates with vasopressor-resistant hypotension, the serum levels of cortisol were within normal nonstress range. There was a strong negative linear association between postnatal age and dehydroepiandrosterone level (r = −0.50, p .05). The cause of therapy-resistant hypotension did not appear to influence the steroid levels. Conclusions: Cortisol stress response is absent in these severely ill late preterm and term infants. This may be due to inhibition of the distal pathway of cortisol synthesis. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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