| Autor: |
Shroff, Rukshana, Eisenhauer, Anton, Heuser, Alexander, Kolevica, Ana, D'haese, Patrick, Shanahan, Catherine, Evenepoel, Pieter |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| DOI: |
10.1093/ndt/gfad063c_3539 |
| Popis: |
Background and Aims Dysregulated mineral homeostasis is common in chronic kidney disease (CKD) and associated with bone demineralization and vascular calcification. The balance between bone formation and resorption, which reflect the bone calcium (Ca) balance (BCaB), cannot be determined without bone biopsy which is invasive and not easily repeatable. Recently, we have shown that stable (i.e. non-radioactive) Ca isotopes, 42Ca and 44Ca, can be measured in serum and their ratio (δ44/42Caserum) quantitatively determines net bone gain or loss of Ca. Thus, when bone formation exceeds bone resorption, the net BCaB is positive and δ44/42Caserum is high, and when bone resorption is the predominant process δ44/42Caserum is low compared to age-matched controls. In this study we compared δ44/42Caserum against δ44/42Cabone and arterial biopsy samples (δ44/42Caartery) and the sensitivity of δ44/42Ca in predicting changes in bone histology. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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