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Charles Univerzity, Faculty of Pharmacy in Hradec Králové Department: Department of Pharmacognosy and Pharmaceutical botany Author: Markéta Šímová Supervisor: PharmDr. Daniela Hulcová Ph.D. Title of thesis: Active substances used in clinical practice originating in plant sources Key words: active substance, plant source, development, analgesics, local anesthetics, antineoplastics, sympathomimetics, parasympathomimetics, parasympatholytics, antispasmodics. Since time immemorial, plants have been used to treat various diseases, but it is not known what is behind their healing effect. It managed to find out with the development of pharmacy and chemistry. The first substances were isolated and their mechanism of action was elucidated. It was found that the substances themselves have a better and more efficient effect than the mixture, but also a number of side effects. The effort of experts was to remove them, which managed to prepare a lot of derivatives and in many cases they had even higher effect. With the development of new technologies, synthetically produced substances have come to the fore and it is already forgotten that many clinically used drugs have their origins in nature. This thesis deals with substances that originate in plant sources and are used in clinical practice as medicinal... |
