Synthesis of 4-alkylidenepyrazolones and their use in preparation of spirocycles

Autor: Boudová, Hana
Přispěvatelé: Veselý, Jan, Matoušová, Eliška
Jazyk: čeština
Rok vydání: 2021
Předmět:
Popis: Due to the wide use of spirocyclic compounds containing heterocycles, especially in medicinal chemistry, this bachelor thesis deals with the preparation of 4-alkylidenepyrazolones and their use to prepare pyrazolone-derived spirocyclic compounds using organocatalysis with tertiary amines. 4-Alkylidenepyrazolones were prepared by Knoevenagel condensation of pyrazolones and aldehydes, the preparation of spiropyrazolones was carried out by the cyclization reaction of 3-nitropropyl-mesylate with suitable 4-alkylidenepyrazolone derivatives. Key words 4-alkylidenpyrazolones, α,β-unsaturated pyrazolones, Knoevenagel reaction, 3-nitropropyl-mesylate, spirocyclic compounds, spiropyrazolones, organocatalysis
Databáze: OpenAIRE