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CHARLES UNIVERSITY Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Technology Candidate: Mgr. Dagmar Stehlíková Consultant: PharmDr. Eva Šnejdrová, Ph.D. Title of Thesis: Evaluation of rheological properties of terbinafine hydrochloride creams The aim of the rigorous work was to evaluate the rheological properties of creams with terbinafine hydrochloride at different stages of the formulation of a generic preparation using a suitable methodology and their comparison with the commercial preparation Lamisil 10 mg/g crm. (GlaxoSmithKline), which was specified as a standard. The theoretical part deals with the characterization of generic drugs, pharmaceutical and therapeutic equivalence. Tests suitable for measuring the flow properties of semi-solid preparations and evaluation methods are presented. The properties of terbinafine hydrochloride and the process of developing generic semi-solid formulations are summarized. Testing was performed at 25 řC on a Kinexus Pro+ rotational rheometer using cone-plate geometry. The flow properties of the creams were evaluated by nonequilibrium flow and viscosity curves, which were analysed by the power law model and Herschel-Bulkely model. The coefficient of consistency, the index of flow behaviour and the yield point were expressed. The... |
