| Popis: |
A secretory pathway is a process which serves for maturation of approximately one third of nascent polypeptides during proteosynthesis. Correct function of each membrane protein depends on their effective transport into its target membrane. An important group of proteins interacting with maturating proteins and ensuring their pass through the secretory pathway are cargo receptors. Cargo receptors help to insert nascent proteins into COPII vesicles via which they are exported from endoplasmic reticulum to Golgi apparatus. Erv14 belongs to characterized cargo receptors in yeast. Based on similarity with this cargo receptor several homologous cargo receptors were also identified in higher eukaryotes, including human. Na+ /H+ antiporters are among membrane proteins passing the secretory pathway and requiring a cargo receptor for their biogenesis. The aim of this work is to summarize knowledge of the role of Erv14 cargo receptor and its human homologs CNIH1-4 in biogenesis of monovalent cation transporters, including Na+ /H+ antiporters. Key words: Na+ /H+ antiporters, Erv14, CNIH, cargo receptors, secretory pathway |
