Macrocycles and complexation of large metal cations
| Autor: | Faltejsek, Jan |
|---|---|
| Přispěvatelé: | Hermann, Petr, Drahoš, Bohuslav |
| Jazyk: | čeština |
| Rok vydání: | 2023 |
| Předmět: |
paramagnetické komplexy
kinetická měření komplexy lanthanoidů radiochemistry macrocyclic complexes izomerizace radiochemie reakční mechanismy NMR spectra makrocyklické komplexy krystalové struktury spektra NMR lanthanide complexes makrocyklické ligandy crystal structures kinetic measurements isomerization macrocyclic ligands reaction mechanisms paramagnetic complexes |
| Popis: | In the last years, radioisotopes of heavy elements from the bottom of the Periodic Table have been increasingly used in nuclear medicine with focus on alpha-therapy. These large metal ions demand ligands fulfilling their special requirements. Complexes of polyazamacrocyclic ligands have been used in radiomedicine for a long time as diagnostic and therapeutic agents. This work aims to con- tribute to understanding of coordination chemistry of large macrocycles toward large metal ions. Thus, this work deals with structural studies, formation and decomplexation kinetics of Ln(III)-H4pyta complexes employing X-ray solid-state and solution NMR/UV-Vis spectroscopic data. The H4pyta is a 18-membered hexaazamacrocycle formed by two pyridine units and four amine groups which are modified with four acetate pendant arms. In the solid state, several isomeric complexes were structu- rally characterized. Large Ln(III) ions form decacoordinated species with two and two acetates on each side of the macrocyclic N6-plane. Small Ln(III) binds the ligand in a nonadentate fashion with one pendant non-coordinated. In the middle of lanthanide series, both isomers were characterized for several Ln(III) ions. Formation of the complexes takes place in a three-step mechanism with fast formation of an out-of-cage intermediate... |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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