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This Bachelor's thesis focuses on benefits of neoadjuvant therapy for colorectal cancer. The thesis is divided into a theoretical and a practical part. The theoretical part contains data I have compiled from available literature, scholarly articles and professional websites. I concentrated most closely on colon and rectal anatomy, screening, diagnosis and treatment of colorectal cancer. The aim of the Bachelor's thesis is to compare the extent of colorectal cancer before and after neoadjuvant therapy. Furthermore, the second aim is to determine the number of radically operated patients after preoperative treatment. The practical part consists of data from the archive of medical records at the Department of Oncology in the České Budějovice Hospital, a. s. The observed factors were age and gender of the patient, diagnosis, localization and TNM classification, type of neoadjuvant therapy, initiation and termination of therapy, type of operation and its initiation. The last factor was the extent of disease after surgery. In total, I evaluated 50 patients who met the criteria. I processed the data into comprehensive graphs and spreadsheets. The collected data show an improvement in the extent of disease in 84 % of patients. 5 % of patients had the same TNM classification and the disease worsened in 11 % of patients. Complete or nearly complete remission occurred in 6 patients (14 %). 88 % of patients from the whole research group were radically operated. 20 patients (40 %) underwent rectal resection and 24 patients (48 %) underwent rectal amputation. 6 remaining patients did not have any surgery. Two patients had an inoperable tumour, others were not operated due to their high age, weight or because it was their wish. The results from the practical part can provide feedback to the Department of Oncology in the České Budějovice Hospital. Next, it can also serve as a study material for students and the general public. |
