| Popis: |
Sepsis, or life-threatening organ dysfunction caused by deregulated host response to the presence of infection, is one of the most significant causes of death caused by infection diseases worldwide. 31.5 million patients get sick with sepsis annually and 5.3 million of them die. Sepsis is characterised by homeostatic dysbalance, which can lead to septic shock or even to death. Sepsis may also result in development of multiorgan dysfunction or damage to several organs at the same time. Especially heart, kidneys, liver, lungs, central nervous system and blood elements belong among the organs affected by sepsis. One of the most affected organs is the heart, impairment of which is accompanied with the development of myocardial depression, which contributes to the increase of mortality from sepsis. The precise mechanisms leading to septic myocardial depression have not been fully explained yet, nevertheless mitochondria appear to play an important role in this process. Due to sepsis, many mitochondrial functions are disrupted, which is subsequently manifested by the depletion of cellular energy stores, resulting in myocardial depression. In our laboratories, we managed to create a clinically relevant model of sepsis and septic shock, specifically sepsis caused by fecal peritonitis in domestic pigs, that... |
