| Autor: |
Karalexi, M.A. Dessypris, N. Ma, X. Spector, L.G. Marcotte, E. Clavel, J. Pombo-de-Oliveira, M.S. Heck, J.E. Roman, E. Mueller, B.A. Hansen, J. Auvinen, A. Lee, P.-C. Schüz, J. Magnani, C. Mora, A.M. Dockerty, J.D. Scheurer, M.E. Wang, R. Bonaventure, A. Kane, E. Doody, D.R. Baka, M. Moschovi, M. Polychronopoulou, S. Kourti, M. Hatzipantelis, E. Pelagiadis, I. Dana, H. Kantzanou, M. Tzanoudaki, M. Anastasiou, T. Grenzelia, M. Gavriilaki, E. Sakellari, I. Anagnostopoulos, A. Kitra, V. Paisiou, A. Bouka, E. Nikkilä, A. Lohi, O. Erdmann, F. Kang, A.Y. Metayer, C. Milne, E. Petridou, E.T. NARECHEM-ST Group FRECCLE Group |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Popis: |
Aim: Evidence for an association of foetal growth with acute myeloid leukaemia (AML) is inconclusive. AML is a rare childhood cancer, relatively more frequent in girls, with distinct features in infancy. In the context of the Childhood Leukemia International Consortium (CLIC), we examined the hypothesis that the association may vary by age, sex and disease subtype using data from 22 studies and a total of 3564 AML cases. Methods: Pooled estimates by age, sex and overall for harmonised foetal growth markers in association with AML were calculated using the International Fetal and Newborn Growth Consortium for the 21st Century Project for 17 studies contributing individual-level data; meta-analyses were, thereafter, conducted with estimates provided ad hoc by five more studies because of administrative constraints. Subanalyses by AML subtype were also performed. Results: A nearly 50% increased risk was observed among large-for-gestational-age infant boys (odds ratio [OR]: 1.49, 95% confidence interval [CI]: 1.03–2.14), reduced to 34% in boys aged |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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