Inflammation associates with impaired small arterial elasticity early in HIV disease

Autor: Peterson, T.E. Hullsiek, K.H. Engen, N.W. Kumarasamy, N. Lebech, A.-M. Liappis, A. Papadopoulos, A. Polizzotto, M.N. Schreiner, P.J. Duprez, D. Baker, J.V. INSIGHT START (Strategic Timing of AntiRetroviral Treatment) Study Group
Jazyk: angličtina
Rok vydání: 2018
Popis: We estimated small arterial elasticity and used linear regression to evaluate its association with inflammatory biomarkers among antiretroviral therapy-naïve, HIV-positive patients with high CD4+ counts. After adjustment, high-sensitivity C-reactive protein and interleukin-6 were inversely associated with small arterial elasticity. These data suggest that systemic inflammation may contribute to vascular dysfunction even in very early HIV disease. © The Author(s) 2018.
Databáze: OpenAIRE