| Autor: |
Mavreli, D. Lykoudi, A. Lambrou, G. Papaioannou, G. Vrachnis, N. Kalantaridou, S. Papantoniou, N. Kolialexi, A. |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Popis: |
Background/Aim: To characterize global microRNA (miRNA) expression profile in the first trimester maternal plasma of women who subsequently develop lateonset preeclampsia (LOPE) compared to uncomplicated pregnancies. Materials and Methods: Five first trimester plasma samples from women who developed LOPE and 5 controls were analyzed using next generation sequencing technology (NGS) followed by target prediction, Gene Ontology analysis and pathway identification. Quantitative real-time polymerase chain reaction (qRT-PCR) was performed for confirmation in an independent cohort of 12 LOPE cases and 12 controls. Results: miR-23b-5p and miR- 99b-5p were down-regulated by >1.5 fold in LOPE complicated pregnancies (p value |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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