Effect of Immediate Initiation of Antiretroviral Treatment in HIV-Positive Individuals Aged 50 Years or Older

Autor: Lodi, S. Costagliola, D. Sabin, C. Del Amo, J. Logan, R. Abgrall, S. Reiss, P. Van Sighem, A. Jose, S. Blanco, J.-R. Hernando, V. Bucher, H.C. Kovari, H. Segura, F. Ambrosioni, J. Gogos, C.A. Pantazis, N. Dabis, F. Vandenhende, M.-A. Meyer, L. Seng, R. Gill, M.J. Krentz, H. Phillips, A.N. Porter, K. Grinsztejn, B. Pacheco, A.G. Muga, R. Tate, J. Justice, A. Hernán, M.A.
Jazyk: angličtina
Rok vydání: 2017
Popis: Background: Clinical guidelines recommend immediate initiation of combined antiretroviral therapy for all HIV-positive individuals. However, those guidelines are based on trials of relatively young participants. Methods: We included HIV-positive antiretroviral therapy-naive, AIDS-free individuals aged 50-70 years after 2004 in the HIV-CAUSAL Collaboration. We used the parametric g-formula to estimate the 5-year risk of all-cause and non-AIDS mortality under (1) immediate initiation at baseline and initiation at CD4 count, (2)
Databáze: OpenAIRE