| Autor: |
Paparrigopoulos, Thomas Liappas, John Tzavellas, Elias and Mourikis, Iraklis Soldatos, Constantin |
| Jazyk: |
angličtina |
| Rok vydání: |
2007 |
| Předmět: |
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| Popis: |
Background: Although amisulpride is considered to be a prolactin-raising atypical antipsychotic drug, a limited number of studies have documented the extent of its prolactin-elevating properties. In the present study the effect of amisulpride on plasma levels of prolactin and the reversibility of this untoward side effect were investigated. Methods: 17 patients with various diagnoses received amisulpride (50-800 mg/day) or a combination of amisulpride plus other medication as needed. Plasma prolactin was determined 26.7 +/- 9.4 days (range: 13-50 days) after initiation of treatment and in 3 cases after a much longer period, and 14-51 days following its withdrawal. Results: All patients on amisulpride had hyperprolactinemia, (mean +/- S.D. prolactin levels: 62.5 +/- 33.0 ng/ml) with females exhibiting considerably higher prolactin levels than males. Following amisulpride discontinuation prolactin levels were significantly (p < 000) reduced (mean S.D. prolactin levels: 12.3 +/- 6.7 ng/ml). No significant correlation was detected between prolactin levels and either amisulpride dosage or duration of administration. Conclusion: Amisulpride has a pronounced prolactin-elevating effect which appears to be independent of dosage and duration of administration. Hyperprolactinemia rapidly reverses following amisulpride discontinuation. (c) 2006 Elsevier Inc. All rights reserved. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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