| Autor: |
Rothman, Nathaniel Garcia-Closas, Montserrat Chatterjee, Nilanjan Malats, Nuria Wu, Xifeng Figueroa, Jonine D. and Real, Francisco X. Van den Berg, David Matullo, Giuseppe and Baris, Dalsu Thun, Michael Kiemeney, Lambertus A. Vineis, Paolo De Vivo, Immaculata Albanes, Demetrius Purdue, Mark P. and Rafnar, Thorunn Hildebrandt, Michelle A. T. Kiltie, Anne E. and Cussenot, Olivier Golka, Klaus Kumar, Rajiv Taylor, Jack A. Mayordomo, Jose I. Jacobs, Kevin B. Kogevinas, Manolis and Hutchinson, Amy Wang, Zhaoming Fu, Yi-Ping and Prokunina-Olsson, Ludmila Burdett, Laurie Yeager, Meredith and Wheeler, William Tardon, Adonina Serra, Consol Carrato, Alfredo Garcia-Closas, Reina Lloreta, Josep Johnson, Alison and Schwenn, Molly Karagas, Margaret R. Schned, Alan and Andriole, Jr., Gerald Grubb, III, Robert Black, Amanda and Jacobs, Eric J. Diver, W. Ryan Gapstur, Susan M. Weinstein, Stephanie J. Virtamo, Jarmo Cortessis, Victoria K. and Gago-Dominguez, Manuela Pike, Malcolm C. Stern, Mariana C. and Yuan, Jian-Min Hunter, David J. McGrath, Monica Dinney, Colin P. Czerniak, Bogdan Chen, Meng Yang, Hushan and Vermeulen, Sita H. Aben, Katja K. Witjes, J. Alfred and Makkinje, Remco R. Sulem, Patrick Besenbacher, Soren and Stefansson, Kari Riboli, Elio Brennan, Paul Panico, Salvatore Navarro, Carmen Allen, Naomi E. Bueno-de-Mesquita, H. Bas Trichopoulos, Dimitrios Caporaso, Neil Landi, Maria Teresa Canzian, Federico Ljungberg, Borje Tjonneland, Anne and Clavel-Chapelon, Francoise Bishop, David T. Teo, Mark T. W. and Knowles, Margaret A. Guarrera, Simonetta Polidoro, Silvia and Ricceri, Fulvio Sacerdote, Carlotta Allione, Alessandra and Cancel-Tassin, Geraldine Selinski, Silvia Hengstler, Jan G. and Dietrich, Holger Fletcher, Tony Rudnai, Peter Gurzau, Eugen and Koppova, Kvetoslava Bolick, Sophia C. E. Godfrey, Ashley and Xu, Zongli Sanz-Velez, Jose I. Garcia-Prats, Maria D. and Sanchez, Manuel Valdivia, Gabriel Porru, Stefano Benhamou, Simone Hoover, Robert N. Fraumeni, Jr., Joseph F. Silverman, Debra T. Chanock, Stephen J. |
| Jazyk: |
angličtina |
| Rok vydání: |
2010 |
| Popis: |
We conducted a multi-stage, genome-wide association study of bladder cancer with a primary scan of 591,637 SNPs in 3,532 affected individuals (cases) and 5,120 controls of European descent from five studies followed by a replication strategy, which included 8,382 cases and 48,275 controls from 16 studies. In a combined analysis, we identified three new regions associated with bladder cancer on chromosomes 22q13.1, 19q12 and 2q37.1: rs1014971, (P = 8 x 10(-12)) maps to a non-genic region of chromosome 22q13.1, rs8102137 (P = 2 x 10(-11)) on 19q12 maps to CCNE1 and rs11892031 (P = 1 x 10(-7)) maps to the UGT1A cluster on 2q37.1. We confirmed four previously identified genome-wide associations on chromosomes 3q28, 4p16.3, 8q24.21 and 8q24.3, validated previous candidate associations for the GSTM1 deletion (P = 4 x 10(-11)) and a tag SNP for NAT2 acetylation status (P = 4 x 10(-11)), and found interactions with smoking in both regions. Our findings on common variants associated with bladder cancer risk should provide new insights into the mechanisms of carcinogenesis. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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