Tissue factor expression in neutrophil extracellular traps and neutrophil derived microparticles in antineutrophil cytoplasmic antibody associated vasculitis may promote thromboinflammation and the thrombophilic state associated with the disease

Autor: Kambas, K. Chrysanthopoulou, A. Vassilopoulos, D. Apostolidou, E. Skendros, P. Girod, A. Arelaki, S. Froudarakis, M. Nakopoulou, L. Giatromanolaki, A. Sidiropoulos, P. Koffa, M. Boumpas, D.T. Ritis, K. Mitroulis, I.
Jazyk: angličtina
Rok vydání: 2014
Předmět:
Popis: Objectives: Antineutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV) is characterised by neutrophil activation. An elevated prevalence of venous thromboembolic events has been reported in AAV. Because of the critical role of neutrophils in inflammation associated thrombosis, we asked whether neutrophil tissue factor (TF) may be implicated in the thrombotic diathesis in AAV.
Databáze: OpenAIRE