Early Relapse After Autologous Transplant Is Associated With Very Poor Survival and Identifies an Ultra-High-Risk Group of Patients With Myeloma

Autor: Kastritis, E. Roussou, M. Eleutherakis-Papaiakovou, E. Gavriatopoulou, M. Migkou, M. Gika, D. Fotiou, D. Kanellias, N. Ziogas, D.C. Ntanasis-Stathopoulos, I. Mparmparousi, D. Gatou, A. Katopi, D. Manios, E. Liontos, M. Giannouli, S. Tsirigotis, P. Terpos, E. Dimopoulos, M.A.
Jazyk: angličtina
Rok vydání: 2020
Popis: Introduction: Patients relapsing early after autologous stem cell transplantation (ASCT) are a particular therapeutic challenge. Methods: This was a retrospective, single center study that included 297 consecutive patients that received first-line ASCT Results: We identified 43 (14.5%) patients that relapsed within 5 years (P < .001) and the median post-ASCT survival was 18 months versus >6 years. The survival after an early relapse has not improved significantly over time. In multivariate analysis, early relapse (hazard ratio, 14; P < .001) was the most important prognostic factor for poor survival after ASCT. Conclusion: Patients relapsing
Databáze: OpenAIRE