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It has been suggested that cytokine release during DKA may result in capillary perturbation and thus may contribute to the development of its acute clinical complications (i.e.cerebral or pulmonary edema). We studied in 38 newly diagnosed T1DM children with DKA, aged 7.68 +/- 3.07 years, plasma levels of cytokines IL-1 beta(interleukin-1 beta), IL-2, IL-6, IL-8, IL-10, TNF-alpha (tumour necrosis factor-alpha) and also WBC (white blood cell count), hs-CRP (high sensitivity C-reactive protein), OH (growth hormone) and cortisol, prior to, during and 120h after DKA management, with the aim to monitor their levels at different time-points and in different degrees of DKA severity. Prior to DKA management the levels of IL-6, IL-8, IL-10, WBC and cortisol were elevated, but were all reduced within 120h after DKA management. Then the patients were divided into two groups: a. moderate/severe: pH 7.2. In the group with moderate/severe DKA (ph |
