| Autor: |
Fitzgerald, Sean Rossi, Rosanna Mereuta, Oana Madalina and Jabrah, Duaa Okolo, Adaobi Douglas, Andrew Molina Gil, Sara and Pandit, Abhay McCarthy, Ray Gilvarry, Michael Dunker, Dennis Nordanstig, Annika Ceder, Erik Redfors, Petra and Jood, Katarina Dehlfors, Niclas Magoufis, Georgios and Tsivgoulis, Georgios Brinjikji, Waleed Kallmes, David F. and O'Hare, Alan Power, Sarah Brennan, Paul Alderson, Jack and Nagy, Andras Vadasz, Agnes Psychogios, Klearchos Szikora, Istvan Tatlisumak, Turgut Rentzos, Alexandros Thornton, John and Doyle, Karen M. |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
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| Popis: |
Background Initial studies investigating correlations between stroke etiology and clot composition are conflicting and do not account for clot size as determined by area. Radiological studies have shown that cardioembolic strokes are associated with shorter clot lengths and lower clot burden than non-cardioembolic clots. Objective To report the relationship between stroke etiology, extracted clot area, and histological composition at each procedural pass. Methods As part of the multi-institutional RESTORE Registry, the Martius Scarlett Blue stained histological composition and extracted clot area of 612 per-pass clots retrieved from 441 patients during mechanical thrombectomy procedures were quantified. Correlations with clinical and procedural details were investigated. Results Clot composition varied significantly with procedural passes; clots retrieved in earlier passes had higher red blood cell content (H4=11.644, p=0.020) and larger extracted clot area (H4=10.730, p=0.030). Later passes were associated with significantly higher fibrin (H4=12.935, p=0.012) and platelets/other (H4=15.977, p=0.003) content and smaller extracted clot area. Large artery atherosclerotic (LAA) clots were significantly larger in the extracted clot area and more red blood cell-rich than other etiologies in passes 1-3. Cardioembolic and cryptogenic clots had similar histological composition and extracted clot area across all procedural passes. Conclusion LAA clots are larger and associated with a large red blood cell-rich extracted clot area, suggesting soft thrombus material. Cardioembolic clots are smaller in the extracted clot area, consistent in composition and area across passes, and have higher fibrin and platelets/other content than LAA clots, making them stiffer clots. The per-pass histological composition and extracted clot area of cryptogenic clots are similar to those of cardioembolic clots, suggesting similar formation mechanisms. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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