| Autor: |
Aleksandrova, Krasimira Boeing, Heiner Jenab, Mazda and Bueno-de-Mesquita, H. Bas Jansen, Eugene van Duijnhoven, Franzel J. B. Fedirko, Veronika Rinaldi, Sabina Romieu, Isabelle and Riboli, Elio Romaguera, Dora Overvad, Kim Ostergaard, Jane Nautrup Olsen, Anja Tjonneland, Anne Boutron-Ruault, Marie-Christine Clavel-Chapelon, Francoise Morois, Sophie and Masala, Giovanna Agnoli, Claudia Panico, Salvatore Tumino, Rosario Vineis, Paolo Kaaks, Rudolf Lukanova, Annekatrin and Trichopoulou, Antonia Naska, Androniki Bamia, Christina and Peeters, Petra H. Rodriguez, Laudina Buckland, Genevieve and Sanchez, Maria-Jose Dorronsoro, Miren Huerta, Jose-Maria and Barricarte, Aurelio Hallmans, Goran Palmqvist, Richard Khaw, Kay-Tee Wareham, Nicholas Allen, Naomi E. Tsilidis, Konstantinos K. Pischon, Tobias |
| Jazyk: |
angličtina |
| Rok vydání: |
2011 |
| Popis: |
Metabolic syndrome (MetS) is purportedly related to risk of developing colorectal cancer; however, the association of MetS, as defined according to recent international criteria, and colorectal cancer has not been yet evaluated. In particular, it remains unclear to what extent the MetS components individually account for such an association. We addressed these issues in a nested case-control study that included 1,093 incident cases matched (1: 1) to controls by using incidence density sampling. Conditional logistic regression was used to estimate relative risks (RR) and 95% CIs. MetS was defined according to the criteria of the National Cholesterol Education Program/Adult Treatment Panel III (NCEP/ATPIII), the International Diabetes Federation (IDF), and the 2009 harmonized definition. Among individual components, abdominal obesity (RR = 1.51; 95% CI: 1.16-1.96) was associated with colon cancer, whereas abnormal glucose metabolism was associated with both colon (RR = 2.05; 95% CI: 1.57-2.68) and rectal cancer (RR = 2.07; 95% CI: 1.45-2.96). MetS, as defined by each of the definitions, was similarly associated with colon cancer (e. g., RR = 1.91; 95% CI: 1.47-2.42 for MetS by NCEP/ATPIII), whereas MetS by NCEP/ATPIII, but not IDF or harmonized definition, was associated with rectal cancer (RR = 1.45; 95% CI: 1.02-2.06). Overall, these associations were stronger in women than in men. However, the association between MetS and colorectal cancer was accounted for by abdominal obesity and abnormal glucose metabolism such that MetS did not provide risk information beyond these components (likelihood ratio test P = 0.10 for MetS by NCEP/ATPIII). These data suggest that simple assessment of abnormal glucose metabolism and/or abdominal obesity to identify individuals at colorectal cancer risk may have higher clinical utility than applying more complex MetS definitions. Cancer Prev Res; 4(11); 1873-83. (C) 2011 AACR. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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