| Autor: |
Bassetti, M. Giacobbe, D.R. Vena, A. Trucchi, C. Ansaldi, F. Antonelli, M. Adamkova, V. Alicino, C. Almyroudi, M.-P. Atchade, E. Azzini, A.M. Carannante, N. Carnelutti, A. Corcione, S. Cortegiani, A. Dimopoulos, G. Dubler, S. García-Garmendia, J.L. Girardis, M. Cornely, O.A. Ianniruberto, S. Kullberg, B.J. Lagrou, K. Le Bihan, C. Luzzati, R. Malbrain, M.L.N.G. Merelli, M. Marques, A.J. Martin-Loeches, I. Mesini, A. Paiva, J.-A. Peghin, M. Raineri, S.M. Rautemaa-Richardson, R. Schouten, J. Brugnaro, P. Spapen, H. Tasioudis, P. Timsit, J.-F. Tisa, V. Tumbarello, M. Van Den Berg, C.H.S.B. Veber, B. Venditti, M. Voiriot, G. Wauters, J. Montravers, P. |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Popis: |
Background: The objective of this study was to assess the cumulative incidence of invasive candidiasis (IC) in intensive care units (ICUs) in Europe. Methods: A multinational, multicenter, retrospective study was conducted in 23 ICUs in 9 European countries, representing the first phase of the candidemia/intra-abdominal candidiasis in European ICU project (EUCANDICU). Results: During the study period, 570 episodes of ICU-acquired IC were observed, with a cumulative incidence of 7.07 episodes per 1000 ICU admissions, with important between-center variability. Separated, non-mutually exclusive cumulative incidences of candidemia and IAC were 5.52 and 1.84 episodes per 1000 ICU admissions, respectively. Crude 30-day mortality was 42%. Age (odds ratio [OR] 1.04 per year, 95% CI 1.02-1.06, p < 0.001), severe hepatic failure (OR 3.25, 95% 1.31-8.08, p 0.011), SOFA score at the onset of IC (OR 1.11 per point, 95% CI 1.04-1.17, p 0.001), and septic shock (OR 2.12, 95% CI 1.24-3.63, p 0.006) were associated with increased 30-day mortality in a secondary, exploratory analysis. Conclusions: The cumulative incidence of IC in 23 European ICUs was 7.07 episodes per 1000 ICU admissions. Future in-depth analyses will allow explaining part of the observed between-center variability, with the ultimate aim of helping to improve local infection control and antifungal stewardship projects and interventions. © 2019 The Author(s). |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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