Maternal genital colonization with Ureaplasma urealyticum promotes preterm delivery: Association of the respiratory colonization of premature infants with chronic lung disease and increased mortality

Autor: Kafetzis, DA Skevaki, CL Skouteri, V Gavrili, S Peppa, K and Kostalos, C Petrochilou, V Michalas, S
Jazyk: angličtina
Rok vydání: 2004
Popis: Background. Infection of the chorioamnion with Ureaplasma urealyticum has been associated with low birth weight. Respiratory tract colonization in preterm infants has been associated with the development of chronic lung disease (CLD). The purpose of the present study was to determine the frequency of colonization of the mother’s vagina and the preterm infant’s respiratory tract and to associate U. urealyticum with premature birth and with development of CLD in the newborn. Methods. The present prospective study involved 126 mothers with preterm delivery and 125 mothers with full-term delivery, as well as their offspring. Vaginal secretion specimens were obtained from each mother before delivery. Rhinopharyngeal secretion or tracheal lavage specimens were collected after the birth of each premature and full-term infant and then periodically during hospitalization. Results. Vaginal Ureaplasma colonization occurred among 36.5% of mothers with preterm delivery and among 38% of mothers with full-term delivery. The rate of vertical transmission was 33% and 17% for mothers with preterm delivery and mothers with full-term delivery, respectively. The transmission rate for infants, according to birth weight, was as follows: 60%, for infants with a birth weight of
Databáze: OpenAIRE