Formal total synthesis of (+)-12-deoxyscalarolide
| Autor: | Ragoussis, V. Liapis, M. Ragoussis, N. |
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| Jazyk: | angličtina |
| Rok vydání: | 1990 |
| Popis: | An effective formal total synthesis of (+)-12-deoxyscalarolide is described, starting from natural manool. Two alternative reaction schemes have been investigated for the synthesis of the tetracarbocyclic key intermediate (-)-methyl 17-oxo-24-norscalaran-25-oate. The unsaturated lactonic ring is then created from this ester in three steps to afford, in high yield, the (-)-scalar-16-en-25,24-olide which is easily isomerised under basic conditions to (+)-12-deoxyscalarolide. |
| Databáze: | OpenAIRE |
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