Replication protein A: A reliable biologic marker of prognostic and therapeutic value in human astrocytic tumors

Autor: Kanakis, D. Levidou, G. Gakiopoulou, H. Eftichiadis, C. Thymara, I. Fragkou, P. Trigka, E.-A. Boviatsis, E. Patsouris, E. Korkolopoulou, P.
Jazyk: angličtina
Rok vydání: 2011
Popis: Replication protein A is a single-stranded DNA-binding protein that is required for the stabilization of single-stranded DNA and identified in replication foci where members of cyclin-dependent kinases-cyclin complexes are also present. In this study, we investigated the expression of replication protein A1 and replication protein A2 subunits of replication protein A protein in correlation with cyclins D2 and D3 and nuclear factor κB expression and assessed their prognostic significance in 66 patients with astrocytomas. Statistically significant positive associations emerged between (a) replication protein A1 and replication protein A2 protein expression (P
Databáze: OpenAIRE