Simple physicochemical properties related with lipophilicity, polarity, molecular size and ionization status exert significant impact on the transfer of drugs and chemicals into human breast milk
| Autor: | Vasios, G. Kosmidi, A. Kalantzi, O.-I. Tsantili-Kakoulidou, A. Kavantzas, N. Theocharis, S. Giaginis, C. |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Popis: | Objectives: The transfer of xenobiotic compounds into human breast milk has raised serious concerns in the last few years. The present study is aimed to assess whether simple physicochemical properties exert significant impact on human breast milk transfer of drugs and chemicals. Methods: A large data set of 375 xenobiotic compounds with available experimental milk to plasma (M/P) ratios was systematically compiled from the literature and explored with their physicochemical properties being further analyzed with respect to their extent to transfer into breast milk. Results: Xenobiotic compounds with increased breast milk transfer (M/P ≥ 1) were characterized by enhanced lipophilicity and decreased molecular size (p |
| Databáze: | OpenAIRE |
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