| Autor: |
Deftereos, Spyridon Giannopoulos, Georgios Kossyvakis, Charalampos Kaoukis, Andreas Raisakis, Konstantinos and Panagopoulou, Vasiliki Ntzouvara, Olga Perpinia, Anastasia and Rentoukas, Ilias Pyrgakis, Vlasios Manolis, Antonios S. and Stefanadis, Christodoulos |
| Jazyk: |
angličtina |
| Rok vydání: |
2011 |
| Popis: |
We hypothesized that uptitration of beta blockade and adjustment of pacing parameters to achieve a prevalence of single chamber atrial inhibited rate-responsive (AAIR) pacing in patients with dual-chamber implantable cardioverter-defibrillators (ICDs) would result in maximization of beta-blocker dosage and thus decrease appropriate ICD therapies. We included patients with ischemic or dilated cardiomyopathy and implanted ICDs without contraindications to beta blockers and atrioventricular conduction disturbances. Two 6-month periods were compared: clinically guided phase (pacing function set at back-up dual-chamber rate-responsive pacing mode at a lower rate of about 40 beats/min) and pacing-guided phase, during which beta-blocker dosage was titrated with a target of achieving >90% AAIR pacing (lower rate 60 beats/min). Sixty-one patients (64.2 +/- 8.3 years old) were included. During the pacing-guided phase the target of >= 90% AAIR pacing was achieved in 80.3% of patients. Mean metoprolol dose during the clinically guided phase was 96.7 +/- 29.4 versus 127.0 +/- 39.6 mg/day in the pacing-guided phase (p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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