| Popis: |
The effects of combined treatment with a heparinoid-sodium pentosan polysulfate - and an antihistamine-promethazine hydrochloride - against thioacetamide-induced rat liver injury were studied. Treatment by promethazine hydrochloride at 0 and 6 hrs by 2.5 and 1.25 mg per 100 g body weight or by 1.5 mg pentosan polysulfate did not afford a real protection against liver injury. The combined, however, of these two incompletely acting schedules treatment inhibited substantially the development of liver cellnecrosis up to 96 hrs. A synergic action of the above protective agents could be supposed. © 1974 Springer-Verlag. |
