Elevated soluble intercellular adhesion molecule-1 levels are associated with poor short-term prognosis in middle-aged patients with acute ischaemic stroke

Autor: Rallidis, Loukianos S. Zolindaki, Maria G. Vikelis, Michalis and Kaliva, Katerina Papadopoulos, Costas Kremastinos, Dimitrios Th.
Jazyk: angličtina
Rok vydání: 2009
Popis: Background: There is increasing evidence that cellular adhesion molecules (CAMs) play an important role in the pathophysiology of acute ischaemic stroke. We examined the prognostic value of soluble intercellular adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM-1) on in-hospital mortality in patients with ischaemic stroke. Methods: We recruited 241 consecutive patients 322 ng/ml were the optimal points that discriminated those who died from the rest of the patients. Conclusions: High sICAM-1 levels on admission are associated with early death in ischaemic middle-aged stroke patients suggesting a pathogenetic role of inflammation in the evolution of ischaemic stroke. (C) 2007 Elsevier Ireland Ltd. All rights reserved.
Databáze: OpenAIRE