| Autor: |
Sakou, Irine-Ikbale Tzanakaki, Georgina Tsolia, Maria N. and Sioumala, Maria Barbouni, Anastasia Kyprianou, Miltiades and Papaevangelou, Vana Tsitsika, Artemis Blackwell, Caroline C. and Kafetzis, Dimitris Kremastinou, Jenny |
| Jazyk: |
angličtina |
| Rok vydání: |
2009 |
| Popis: |
Serogroup C meningococcal conjugate vaccines were introduced in Greece in 2001, and although no cases of serogroup C meningococcal disease were recorded in 2004, a steady increase was observed since 2005. In this study, serum bactericidal activity was assessed in sera of 269 vaccinated children at: a mean time of about 5 years after vaccination. Non-protective antibody titers were observed in most children vaccinated at age 10 years (37.8%) (p < 0.01). Geometric mean concentrations of serum IgG antibodies against serogroup C showed a similar variation. The results indicate that serum bactericidal antibody titers significantly correlate with age of vaccination; most children do not have protective antibody titers few years after immunization in infancy and childhood whereas most adolescents maintain sustained protection. (C) 2009 Elsevier Ltd. All rights reserved. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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