| Autor: |
Chatzisideri, T. Thysiadis, S. Katsamakas, S. Dalezis, P. Sigala, I. Lazarides, T. Nikolakaki, E. Trafalis, D. Gederaas, O.A. Lindgren, M. Sarli, V. |
| Jazyk: |
angličtina |
| Rok vydání: |
2017 |
| Popis: |
A cancer-targeting conjugate 4 of a cyclometalated [N,C,N-Pt(II)] complex bearing a NˆCˆN 1,3-di(2-pyridyl)-benzene with c(RGDyK) peptide as guiding molecule was designed and synthesized for real-time drug delivery monitoring in cancer cells and photodynamic therapy (PDT). This conjugate demonstrates a mild cytostatic effect to six cancer cell lines expressing integrins at different extent, while possessing promising features for PDT. Conjugate 4 demonstrated rapid cell uptake by receptor-mediated endocytosis and efficient generation of 1O2 upon irradiation. Incubation of rat bladder cancer cells AY27 with conjugate 4 (50 μΜ) prior to blue light exposure (5 min) resulted in significant reduction (50%) of cell survival compared to control cells as measured by MTT assay post 24 h after treatment. © 2017 Elsevier Masson SAS |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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