Could cisplatin as a front-line treatment in childhood non-Hodgkin's lymphoma be a promising therapy?

Autor: Papadopoulou, AL Moschovi, M Panagopoulou-Cristaki, M and Anagnostou-Keramida, D Van Vliet-Constantinidou, C Botsonis, A and Tsangaris, GT Tzortzatou-Stathopoulou, F
Jazyk: angličtina
Rok vydání: 1999
Předmět:
Popis: Non-Hodgkin’s lymphomas (NHL) were often erroneously diagnosed as other malignancies and treated accordingly. In this study cisplatin combined with vincristine, cyclophosphamide, and Adriamycin was weal incidentally as a front-line treatment in seven children with NHL, because the initial histologic diagnosis was that of a sarcoma. After reevaluation three patients had Ki-1 anaplastic large cell lymphoma of T-cell origin, two abdominal B-cell diffuse high-grade NHL, one mediastinal diffuse large B-cell lymphoma, and one B-cell lymphoma in the stomach. They received at least two courses of cisplatin combined regimen and continued with other protocol for NHL. All patients showed an extremely: good response from the first course of therapy and the masses vanished completely. They were followed up for a mean time of 29.5 months and are all in complete remission. The data indicate that cisplatin is active against NHL and might be a promising alternative front-like therapy.
Databáze: OpenAIRE