| Autor: |
Ripke, Stephan Neale, Benjamin M. Corvin, Aiden Walters, James T. R. Farh, Kai-How Holmans, Peter A. Lee, Phil and Bulik-Sullivan, Brendan Collier, David A. Huang, Hailiang and Pers, Tune H. Agartz, Ingrid Agerbo, Esben Albus, Margot and Alexander, Madeline Amin, Farooq Bacanu, Silviu A. Begemann, Martin Belliveau, Jr., Richard A. Bene, Judit Bergen, Sarah E. Bevilacqua, Elizabeth Bigdeli, Tim B. Black, Donald W. and Bruggeman, Richard Buccola, Nancy G. Buckner, Randy L. and Byerley, William Cahn, Wiepke Cai, Guiqing Campion, Dominique Cantor, Rita M. Carr, Vaughan J. Carrera, Noa and Catts, Stanley V. Chambert, Kimberly D. Chan, Raymond C. K. and Chen, Ronald Y. L. Chen, Eric Y. H. Cheng, Wei Cheung, Eric F. C. Chong, Siow Ann Cloninger, C. Robert Cohen, David and Cohen, Nadine Cormican, Paul Craddock, Nick Crowley, James J. Curtis, David Davidson, Michael Davis, Kenneth L. and Degenhardt, Franziska Del Favero, Jurgen Demontis, Ditte and Dikeos, Dimitris Dinan, Timothy Djurovic, Srdjan Donohoe, Gary Drapeau, Elodie Duan, Jubao Dudbridge, Frank and Durmishi, Naser Eichhammer, Peter Eriksson, Johan and Escott-Price, Valentina Essioux, Laurent Fanous, Ayman H. and Farrell, Martilias S. Frank, Josef Franke, Lude Freedman, Robert Freimer, Nelson B. Friedl, Marion Friedman, Joseph I. and Fromer, Menachem Genovese, Giulio Georgieva, Lyudmila and Giegling, Ina Giusti-Rodriguez, Paola Godard, Stephanie and Goldstein, Jacqueline I. Golimbet, Vera Gopal, Srihari and Gratten, Jacob de Haan, Lieuwe Hammer, Christian Hamshere, Marian L. Hansen, Mark Hansen, Thomas Haroutunian, Vahram and Hartmann, Annette M. Henskens, Frans A. Herms, Stefan and Hirschhorn, Joel N. Hoffmann, Per Hofman, Andrea Hollegaard, Mads V. Hougaard, David M. Ikeda, Masashi Joa, Inge and Julia, Antonio Kahn, Rene S. Kalaydjieva, Luba and Karachanak-Yankova, Sena Karjalainen, Juha Kavanagh, David and Keller, Matthew C. Kennedy, James L. Khrunin, Andrey Kim, Yunjung Klovins, Janis Knowles, James A. Konte, Bettina and Kucinskas, Vaidutis Kucinskiene, Zita Ausrele Kuzelova-Ptackova, Hana Kahler, Anna K. Laurent, Claudine Keong, Jimmy Lee Chee and Lee, S. Hong Legge, Sophie E. Lerer, Bernard Li, Miaoxin and Li, Tao Liang, Kung-Yee Lieberman, Jeffrey Limborska, Svetlana Loughland, Carmel M. Lubinski, Jan Lonnqvist, Jouko and Macek, Jr., Milan Magnusson, Patrik K. E. Maher, Brion S. and Maier, Wolfgang Mallet, Jacques Marsal, Sara Mattheisen, Manuel Mattingsdal, Morten McCarley, Robert W. McDonald, Colm McIntosh, Andrew M. Meier, Sandra Meijer, Carin J. and Melegh, Bela Melle, Ingrid Mesholam-Gately, Raquelle I. and Metspalu, Andres Michie, Patricia T. Milani, Lili Milanova, Vihra Mokrab, Younes Morris, Derek W. Mors, Ole Murphy, Kieran C. Murray, Robin M. Myin-Germeys, Inez and Mueller-Myhsok, Bertram Nelis, Mari Nenadic, Igor Nertney, Deborah A. Nestadt, Gerald Nicodemus, Kristin K. and Nikitina-Zake, Liene Nisenbaum, Laura Nordin, Annelie and O'Callaghan, Eadbhard O'Dushlaine, Colm O'Neill, F. Anthony and Oh, Sang-Yun Olincy, Ann Olsen, Line Van Os, Jim and Pantelis, Christos Papadimitriou, George N. Papiol, Sergi and Parkhomenko, Elena Pato, Michele T. Paunio, Tiina and Pejovic-Milovancevic, Milica Perkins, Diana O. Pietilainen, Olli and Pimm, Jonathan Pocklington, Andrew J. Powell, John and Price, Alkes Pulver, Ann E. Purcell, Shaun M. Quested, Digby and Rasmussen, Henrik B. Reichenberg, Abraham Reimers, Mark A. and Richards, Alexander L. Roffman, Joshua L. Roussos, Panos and Ruderfer, Douglas M. Salomaa, Veikko Sanders, Alan R. and Schall, Ulrich Schubert, Christian R. Schulze, Thomas G. and Schwab, Sibylle G. Scolnick, Edward M. Scott, Rodney J. and Seidman, Larry J. Shi, Jianxin Sigurdsson, Engilbert and Silagadze, Teimuraz Silverman, Jeremy M. Sim, Kang and Slominsky, Petr Smoller, Jordan W. So, Hon-Cheong Spencer, Chris C. A. Stahl, Eli A. Stefansson, Hreinn Steinberg, Stacy Stogmann, Elisabeth Straub, Richard E. Strengman, Eric and Strohmaier, Jana Stroup, T. Scott Subramaniam, Mythily and Suvisaari, Jaana Svrakic, Dragan M. Szatkiewicz, Jin P. and Soderman, Erik Thirumalai, Srinivas Toncheva, Draga Tosato, Sarah Veijola, Juha Waddington, John Walsh, Dermot Wang, Dai Wang, Qiang Webb, Bradley T. Weiser, Mark and Wildenauer, Dieter B. Williams, Nigel M. Williams, Stephanie and Witt, Stephanie H. Wolen, Aaron R. Wong, Emily H. M. and Wormley, Brandon K. Xi, Hualin Simon Zai, Clement C. Zheng, Xuebin Zimprich, Fritz Wray, Naomi R. Stefansson, Kari and Visscher, Peter M. Adolfsson, Rolf Andreassen, Ole A. and Blackwood, Douglas H. R. Bramon, Elvira Buxbaum, Joseph D. and Borglum, Anders D. Cichon, Sven Darvasi, Ariel Domenici, Enrico Ehrenreich, Hannelore Esko, Tonu Gejman, Pablo V. and Gill, Michael Gurling, Hugh Hultman, Christina M. Iwata, Nakao Jablensky, Assen V. Jonsson, Erik G. Kendler, Kenneth S. Kirov, George Knight, Jo Lencz, Todd Levinson, Douglas F. Li, Qingqin S. Liu, Jianjun Malhotra, Anil K. and McCarroll, Steven A. McQuillin, Andrew Moran, Jennifer L. and Mortensen, Preben B. Mowry, Bryan J. Noethen, Markus M. and Ophoff, Roel A. Owen, Michael J. Palotie, Aarno Pato, Carlos N. Petryshen, Tracey L. Posthuma, Danielle Rietschel, Marcella Riley, Brien P. Rujescu, Dan Sham, Pak C. and Sklar, Pamela St Clair, David Weinberger, Daniel R. and Wendland, Jens R. Werge, Thomas Daly, Mark J. Sullivan, Patrick F. O'Donovan, Michael C. Psychiat Genomics Consortium and Psychosis Endophenotypes Int Conso Wellcome Trust Case-Control Consor |
| Jazyk: |
angličtina |
| Rok vydání: |
2014 |
| Popis: |
Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of alleles, including common alleles of small effect that might be detected by genome-wide association studies. Here we report a multi-stage schizophrenia genome-wide association study of up to 36,989 cases and 113,075 controls. We identify 128 independent associations spanning 108 conservatively defined loci that meet genome-wide significance, 83 of which have not been previously reported. Associations were enriched among genes expressed in brain, providing biological plausibility for the findings. Many findings have the potential to provide entirely new insights into aetiology, but associations at DRD2 and several genes involved in glutamatergic neurotransmission highlight molecules of known and potential therapeutic relevance to schizophrenia, and are consistent with leading pathophysiological hypotheses. Independent of genes expressed in brain, associations were enriched among genes expressed in tissues that have important roles in immunity, providing support for the speculated link between the immune system and schizophrenia. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
