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The distribution of mutations/polymorphisms in genes affecting haemostasis [factor V Leiden (FVL), FV H1298R (FVR2), FII 20210A, b-Fib 455G -> A, FXIII V34L, PAI-1 4G, HPA-1b] among 141 children with thrombosis at various sites and 103 controls was compared. Additionally, the carriage of these mutations/polymorphisms was associated with the levels of their corresponding proteins in thrombosed children. Thrombosis was more frequent in boys (p = 0.021). No studied mutation/polymorphism was found to be a risk factor for thrombosis, except for FVL (odds ratio 3.8, 95% CI 1.4-10.6). The risk of thrombosis for FVL carriers was twice as high in children with an idiopathic thrombosis (odds ratio 5.4) than in thrombosed children with an underlying disease or a triggering event (odds ratio 2.7). FVL carriers had an odds ratio of 5.9 (95% CI 1.8-19.6) when FVR2 was absent. In thrombosed children, the activated protein C resistance ratio was significantly lower in the presence of FVL ( p < 0.001). Prothrombin and fibrinogen levels, although higher in FII 20210A and b-Fib 455G -> A carriers, did not reach statistical significance. Copyright (c) 2006 S. Karger AG, Basel. |
