| Autor: |
Rundle, A. Richie, J. Steindorf, K. Peluso, M. Overvad, K. Raaschou-Nielsen, O. Clavel-Chapelon, F. Linseisen, J.P. Boeing, H. Trichopoulou, A. Palli, D. Krogh, V. Tumino, R. Panico, S. Bueno-De-Mesquita, H.B. Peeters, P.H. Lund, E. Gonzalez, C.A. Martinez, C. Dorronsoro, M. Barricarte, A. Tormo, M.J. Quiros, J.R. Agudo, A. Berglund, G. Jarvholm, B. Bingham, S. Key, T.J. Gormally, E. Saracci, R. Kaaks, R. Riboli, E. Vineis, P. |
| Jazyk: |
angličtina |
| Rok vydání: |
2010 |
| Popis: |
The association between physical activity, potential intermediate biomarkers and lung cancer risk was investigated in a study of 230 cases and 648 controls nested within the European Prospective Investigation of Cancer and Nutrition. Data on white blood cell aromatic-DNA adducts by 32P-post- labelling and glutathione (GSH) in red blood cells were available from a subset of cases and controls. Compared with the first quartile, the fourth quartile of recreational physical activity was associated with a lower lung cancer risk (odds ratio (OR) 0.56, 95% confidence interval (CI) 0.350.90), higher GSH levels (1.87 μmol GSH g-1 haemoglobin, p 0.04) but not with the presence of high levels of adducts (OR 1.05, 95% CI 0.382.86). Despite being associated with recreational physical activity, in these small-scale pilot analyses GSH levels were not associated with lung cancer risk (OR 0.95, 95% CI 0.841.07 per unit increase in GSH levels). Household and occupational activity was not associated with lung cancer risk or biomarker levels. © 2010 Informa UK Ltd. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
